Type I IFN signallingRhinovirus infectionAsthmaCOPDInhaled corticosteroids (ICS) are recommended treatments for all degrees of asthma severity and in combination with bronchodilators are indicated for COPD patients with a history of frequent exacerbations. However, the long-term side effects of ...
type I IFN signalling. Moreover, the intratumoural expression levels of type I IFNs or of IFN-stimulated genes correlate with favourable disease outcome in several cohorts of patients with cancer. Finally, new anticancer immunotherapies are being developed that are based on recombinant type I IF...
Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING doi:10.1038/s41564-023-01546-0BiofilmsFungal host responsePhagocytesThe host type I interferon (IFN) pathway is a major signature of inflammation induced by the human fungal pathogen, Candida albicans. However, ...
MYCOBACTERIUM tuberculosisTuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were shown to correlate with disease severity in ...
Type I interferon (IFN) signalling uses a dual mechanism of action. A Jak-Stat pathway extensively described in mammals involves a cascade of reactions from the interaction of the IFN molecule with its membrane receptor to the stimulation of IFN-induced gene promoters leading in turn to an antiv...
NSs protein of SFTSV is known to perturb type I IFN induction and signalling, but the mechanism remains to be fully understood. Here, we showed the suppression of both type I and type III IFN signalling by SFTSV NSs protein is mediated through inhibition of STAT1 phosphorylation and activation...
To investigate the functions of RNASEH2 in the nervous system and decipher if DNA damage and/or type I IFN signaling drives AGS neuropathology, we generated a murine model of neural Rnaseh2b inactivation. Contrary to previous findings, we show that loss of RNASEH2 function leads to cerebellar...
First, we addressed the influence of IFN-I on transplanted donor cells. To this end, we used a major mismatch allo-HSCT mouse model and administered allogeneic bone marrow (BM) and T cells derived from either Wild-type (WT) or IFNaR1−/−donor mice. WT recipient mice transplanted with...
Type I IFN signalling within humans antagonizes innumerable viruses, such as influenza virus, West Nile virus (WNV), yellow fever virus (YFV), vesicular stomatitis virus (VSV), dengue virus (DENV), herpes simplex virus (HSV) and several hepatitis viruses13. As such, evading type I IFN ...
Regulation of antiviral T cell responses by type I interferons Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different cell types during viral infections. The consequences of type I IFN signalling include direct antiviral activity, innate immune cell activation....