近日,华中科技大学同济医学院附属同济医院汪道文教授团队在《Circulation Research》发表了题为“Epoxyeicosatrienoic Acids Prevent Cardiac Dysfunction in Viral Myocarditis via IFN-I Signaling”的研究论文,该研究确定了sEH抑制和EETs是否在心肌...
2023年6月23日,南方医科大学余潇通讯在Science Advances在线发表了题为“VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation”的研究论文,该研究揭示VANGL2在水泡性口腔炎病毒(VSV)感染期间作为IFN诱导的负反馈调节因子抑制IFN-I信号传导。 从机制上讲,VANGL2与TBK1相互作用,并通...
近日,华南农业大学兽医学院张桂红课题组在美国生物化学与分子生物学会会刊、自然指数收录期刊《Journal of Biological Chemistry》上发表了题为“African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to i...
2023年6月23日,南方医科大学余潇通讯在Science Advances在线发表了题为“VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation”的研究论文,该研究揭示VANGL2在水泡性口腔炎病毒(VSV)感染期间作为IFN诱导的负反馈调节因子抑制IFN-I信号传导。 先天免疫是宿主抵御各种病原体的关键第一...
4. EETs Enhanced Type I IFN Signaling After CVB3 Infection by Targeting TBK1 由于IRF3在病毒感染时诱导I型干扰素表达中发挥着重要作用,因此作者探究了14,15EET和IRF3活化间的潜在关系。结果显示,CVB3感染的AC16细胞引起IRF3 Ser396位点的磷酸化,IRF3dimer形成增加和核转位增加(a-d)。14,15EET(以及11,12EET)...
IFN-I signaling is essential to cytokine responses and recruitment of immune cells, which in turn can promote pathology. In influenza, administration of an agonist to the lipid metabolite sphingosine 1 phosphate receptor (S1P1R) expressed on pDCs was shown to suppress IFN-I signaling in mice ...
We conclude that NDV V protein targets phospho-STAT1 degradation to block IFN-α signaling, which adds novel knowledge to the strategies used by paramyxoviruses to evade IFN. 展开 关键词: NEWCASTLE disease virus VIRAL proteins INTERFERONS CELLULAR signal transduction PROTEIN expression ...
[1]Ethan R. Roy et al. Concerted type Iinterferon signaling in microglia and neural cells promotes memory impairmentassociated with amyloid b plaques. Immunity. 2022. [2]https://medicalxpress.com/news/2022-04-interferon-cognitive-impairment-alzheimer-disease.html ...
严格控制I型干扰素(IFN-I)信号传导对于对抗病毒感染的强大先天免疫反应至关重要,但潜在的分子机制仍然难以捉摸。 2023年6月23日,南方医科大学余潇通讯在Science Advances在线发表了题为“VANGL2 inhibits antiviral IFN-I signaling by targeti...
(AIDS) and non-AIDS morbidity and mortality. Moreover, IFN-I is associated with CD4 T cell depletion and attenuation of antigen-specific T cell responses. Therefore, therapeutic manipulation of IFN-I signaling to improve HIV disease outcome is a source of much interest and debate in the field...