近日,华中科技大学同济医学院附属同济医院汪道文教授团队在《Circulation Research》发表了题为“Epoxyeicosatrienoic Acids Prevent Cardiac Dysfunction in Viral Myocarditis via IFN-I Signaling”的研究论文,该研究确定了sEH抑制和EETs是否在心肌...
近日,华南农业大学兽医学院张桂红课题组在美国生物化学与分子生物学会会刊、自然指数收录期刊《Journal of Biological Chemistry》上发表了题为“African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to i...
Conformal Radiotherapy Efficacy Depends on Monocyte IFN-I SignalingThe ability of monocytes to produce and sense IFN-I determines the efficacy of conformal radiotherapy (CRT).doi:10.1158/2159-8290.CD-RW2023-097Cancer Discovery
2. Wu, J. et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.Science(80-. ). (2013) doi:10.1126/science.1229963. 3. Ishikawa, H., Ma, Z. & Barber, G. N. STING regulates intracellular DNA-mediated, type i interferon-dependent innate ...
We conclude that NDV V protein targets phospho-STAT1 degradation to block IFN-α signaling, which adds novel knowledge to the strategies used by paramyxoviruses to evade IFN. 展开 关键词: NEWCASTLE disease virus VIRAL proteins INTERFERONS CELLULAR signal transduction PROTEIN expression ...
Here, we provide further insight in the transcriptional regulation and the biological implications of STAT2-IRF9 dependent IFN-I signaling. In human STAT1 KO cells overexpressing human STAT2 (U3C-STAT2) we observed that in response to IFN-I STAT2 homodimers interact with IRF9 to regulate ISG...
murinus against viral infection requires macrophages and IFN-I signaling pathways. Consistent with these results, continuous intragastric gavage of gnotobiotic chickens with L. murinus also significantly reduced IBV load in the blood and kidney (Fig. 5i). Lactobacillus murinus-derived metabolite ...
曹雪涛团队再取突破 | I型干扰素(IFN-I)途径的长期激活导致自身免疫性疾病,如系统性红斑狼疮(SLE)。细胞因子信号的代谢调节对细胞稳态至关重要。 近日,中国医学科学院/北京协和医学院/南开大学/海军军医大学曹雪涛团队(徐贺楠和张晓为论文共同第一作者)在Immunity在线发表题为“Cellular spermine targets JAK signaling...
We further investigated the relative sensitivity of all whole-blood cells to circulating IFN-I by measuring the levels of STAT1, a putative marker of IFN-I exposure; phospho-STAT1, a marker of active canonical IFN-I signaling; and phospho-STAT3, a marker of non-canonical IFN-I signaling. ...
et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206, 1465–1472 (2009). Article CAS Google Scholar Seo, S. U. et al. Intestinal macrophages arising from CCR2+ monocytes control pathogen infection by activating innate lymphoid cells...