The interaction between human enteroviruses and type I IFN signaling pathway. Crit. Rev. Microbiol. 2015, 41, 201-207. [CrossRef] [PubMed]摇Lu J, Yi L, Ke C, et al. The interaction between human enteroviruses and type I IFN signaling pathway [ J ] . Crit Rev Microbiol,2015,41(2...
Disruption of the type I interferon (IFN) signaling pathway protects NOD mice from developing lacrimal gland disease. While the impact of B cells later in disease has been well-characterized, the role of B cells in early disease development has not been defined. Here, we performed gene ...
Finally, miR-744 expression was induced by type I IFN in RMCs. Collectively, our data indicate that by targeting PTP1B, miR-744 plays a feed-forward role in regulating type I IFN signaling pathway. These findings give us new insights into the functions of renal miRNAs in regulating ...
Fig 4d:随后作者探究了是否mitochondrial activity可以影响MitoStress诱导type I IFN 和 TNF 信号通路的。分离自ρ0 THP-1 monocytic 或 THP-1 的MitoStress在预先给 pyruvate 或 MitoTEMPO 后 had a reduced potential to induce the expression of IFN-signaling– and TNF-signaling–dependent genes in endothelia...
The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections
Type I IFN signaling constrains IL-17A/F secretion by γδ T cells during bacterial infections. J. Immunol. 184, 3755–3767 (2010). Article CAS PubMed Google Scholar Carrero, J. A. & Unanue, E. R. Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens. Trends ...
Finally, miR-744 expression was induced by type I IFN in RMCs. Collectively, our data indicate that by targeting PTP1B, miR-744 plays a feed-forward role in regulating type I IFN signaling pathway. These findings give us new insights into the functions of renal miRNAs in regulating ...
The signalling pathway of three types of IFNs is mediated respectively through three distinct receptor complexes: a heterodimer of IFNAR1 and IFNAR2 binds type I IFNs; a tetramer consisting of two IFNGR2 chains and two IFNGR1 chains binds dimers of type II IFN; and a heterodimer of IFNLR ...
Here we report that USP38 negatively regulates type I IFN signaling by targeting the active form of TBK1 for degradation in vitro and in vivo. 那么,Result 1就是要确认USP38识别是一个重要的负调节I型干扰素的信号。 为了确定去泛素化酶在抗病毒免疫性中的角色,研究者运用生物信息学方法进行了数据分析...
have shown that IAV infection significantly downregulated miR-302c expression, leading to the activation of IFN-β expression and inhibition of virus replication [12]. Gao et al. have reported that miR-26a activates the type I IFN signaling pathway and promotes the production of IFN-stimulated ...