今天给大家分享一篇中国农业科学院哈尔滨兽医研究所翁长江研究员团队于2024年3月在Journal of Virology上发表了一篇题为“African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway”(非洲猪瘟病毒pH240R通过抑制I型干扰素信号通路来增强病毒复制)的文章。 研究背...
pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infectiondoi:10.1371/journal.ppat.1012613AFRICAN swine fever virusDNA virusesWILD boarSWINE...
同时 GSK3β 抑制剂降低了sEHiΔMyh6心肌细胞中TBK1 和 GSK3β 的磷酸化。Collectively, these data indicate that EETs exert a cardioprotective effect during CVB3 infection through a GSK3β-dependent signaling cascade involving the type I IFN pathway....
Tumor necrosis factor receptor associated factor 3 regulated the signaling pathway of STING/IFN-I for improving the lupus nephritis related podocyte injury and understanding its mechanism Chen Jin-shu1, Chen Pi-hou2, Song Yi-jin1, Wei Jia-xin1, Sun Jing1, Xu Zhi-quan1, , 1. Dep...
近日,华南农业大学兽医学院张桂红教授课题组以华南农业大学兽医学院为第一单位,在Journal of Virology在发表了题为“African Swine Fever Virus MGF505-7R Interacts with Interferon Regulatory Factor 9 to Evade the Type I Interferon Si...
SPF chickens were injected with IFN-I receptor (IFNAR) antibodies to block the IFNA signaling pathway, which was used to validate the effects of microbiota on IFN-I after IBV infection. Compared with that in the PBS control, the secretion of IFN-β in the serum of infected chickens was ...
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Human Bocavirus VP2 up-regulates IFN-β pathway by inhibiting RNF125-mediated ubiquitination of RIG-I (P1411) protein 125 (RNF125), a negative regulator of type I IFN signaling, which conjugates Lysine 48-linked ubiquitination to retinoic-acid-inducible gene-I (RIG-I) and subsequently leads ...