The interaction between human enteroviruses and type I IFN signaling pathway. Crit. Rev. Microbiol. 2015, 41, 201-207. [CrossRef] [PubMed]摇Lu J, Yi L, Ke C, et al. The interaction between human enteroviruses and type I IFN signaling pathway [ J ] . Crit Rev Microbiol,2015,41(2...
Finally, miR-744 expression was induced by type I IFN in RMCs. Collectively, our data indicate that by targeting PTP1B, miR-744 plays a feed-forward role in regulating type I IFN signaling pathway. These findings give us new insights into the functions of renal miRNAs in regulating ...
分离自ρ0 THP-1 monocytic 或 THP-1 的MitoStress在预先给 pyruvate 或 MitoTEMPO 后 had a reduced potential to induce the expression of IFN-signaling– and TNF-signaling–dependent genes in endothelial cells。 Fig 4e:To confirm that MVStressalso induce IFN and TNF signaling, we analyzed the ex...
Finally, miR-744 expression was induced by type I IFN in RMCs. Collectively, our data indicate that by targeting PTP1B, miR-744 plays a feed-forward role in regulating type I IFN signaling pathway. These findings give us new insights into the functions of renal miRNAs in regulating ...
HEK-Blue™ IFN-α/β cellswere generated by stable transfection with the genes encoding humanSTAT2 andIRF9to obtain a fully active type I IFN signaling pathway. The other genes of the pathway (IFNAR1, IFNAR2, JAK1, TyK2, and STAT1) are naturally expressed by these cells. HEK-Blue™...
[Abstract] Type Ⅰ interferonopathy is a type of autoinflammatory diseases caused by single gene mutation, characterized by abnormal activation of type Ⅰ interferon signaling pathway, leading to widespread systemic inflammatory response. In the daily diagnosis and treatment of autoimmune diseases, early...
Here we report that USP38 negatively regulates type I IFN signaling by targeting the active form of TBK1 for degradation in vitro and in vivo. 那么,Result 1就是要确认USP38识别是一个重要的负调节I型干扰素的信号。 为了确定去泛素化酶在抗病毒免疫性中的角色,研究者运用生物信息学方法进行了数据分析...
The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections
Type I interferon (IFN) signalling uses a dual mechanism of action. A Jak-Stat pathway extensively described in mammals involves a cascade of reactions from the interaction of the IFN molecule with its membrane receptor to the stimulation of IFN-induced gene promoters leading in turn to an antiv...
The best-characterized type 1 interferon (IFN) signaling pathway depends on signal transducer and activator of transcription 1 (STAT1) and STAT2. The cytokines can, however, conditionally activate all STATs. Regulation of their access to particular signaling pathways is poorly understood. STAT4 is ...