Type1 IFN signaling on Tregs modulates the migration of Myeloid Derived Suppressor CellsMultiple sclerosis is an autoimmune disorder whose severity is reduced with immune suppressive drugs. Therapeutic intervention with interferon-beta reduces disease exacerbations and delays relapses. The receptor for type...
The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections
Taken together, our findings suggest that USP17 functions through deubiquitination of RIG-I and MDA5 to regulate virus-induced type I IFN signaling. Keywords: USP17; RLR; deubiquitination; type I IFNs Cell Research (2010) 20:802-811. doi:10.1038/cr.2010.41; published online 6 April 2010 ...
HEK-Blue™ IFN-α/β cellswere generated by stable transfection with the genes encoding humanSTAT2 andIRF9to obtain a fully active type I IFN signaling pathway. The other genes of the pathway (IFNAR1, IFNAR2, JAK1, TyK2, and STAT1) are naturally expressed by these cells. HEK-Blue™...
Nonetheless, depending on the duration and intensity of the transduced signaling and/or the nature of the unleashed ISGs, IFN-I can also display protumorigenic effects14, promoting the expression of the immune checkpoint (IC) ligand CD274 (best known as PD-L1)11,15,16. Moreover, innate ...
IFN (Type I/III) Signaling Pathway Antibody Sampler Kit 更多供应商 赛信通(上海)生物试剂有限公司 联系电话: 21-80243558 86218024 产品介绍: 英文名称:IFN (Type I/III) Signaling Pathway Antibody Sampler Kit 基本信息 中文名称IFN (Type I/III) Signaling Pathway Antibody Sampler Kit ...
Figure 6. IL-15 complex restored NK-cell, CD8+ and CD4+ T-cell responses in the absence of type I IFN receptor signaling. IFNAR1−/− and strain-matched wt control mice were either infected with 5 × 106 TCID50 of RV-1B i.n. or dosed with PBS (mock/0 h post infection) in...
LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I Recently, we reported that macroautophagy/autophagy balances type I IFN signaling through selective degradation of ISG15-associated DDX58 via LRRC25. ...
tuberculosis induces an IFN-related gene expression signature in infected primary human macrophages, which is dependent on host type I IFN signaling as well as the mycobacterial virulence factor, region of difference-1. We further demonstrate that type I IFNs selectively limit the production of IL-...
Type I IFN signaling constrains IL-17A/F secretion by γδ T cells during bacterial infections. J. Immunol. 184, 3755–3767 (2010). Article CAS PubMed Google Scholar Carrero, J. A. & Unanue, E. R. Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens. Trends ...