STAT1 N-terminal domain discriminatively controls type I and type II IFN signalingDimerGene expressionMonomerNTDSTAT1The seven signal transducers of transcription (STATs) are cytokine-inducible modular transcription factors. They transmit the stimulation of cells with type I interferons (IFN-α/IFN-β) ...
Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus Wei Fan Bo Wei Richard Bucala Arthritis Research & Therapy(2024) FOXP3+ regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity ...
Type I IFN signaling constrains IL-17A/F secretion by γδ T cells during bacterial infections. J. Immunol. 184, 3755–3767 (2010). Article CAS PubMed Google Scholar Carrero, J. A. & Unanue, E. R. Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens. Trends ...
Differential modulation of type I and type II interferon signaling by severe fever-with-thrombocytopenia syndrome virus NSs protein 2015. Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and ...
This study has shown that IFN-α/β signaling is crucial for combating primary herpes simplex virus type 2 (HSV-2) infection and for responding to immunotherapy using ligands to TLR3, 7 and 9, but not for vaccine-induced immunity. Both genital viral replication and the disease progression wer...
U87MG cells hold a deletion of type I IFN genes, whereas in T98G cells the spontaneous IFN signaling is intact. In response to IFN-α U87MG cells produce much less TRAIL, while other IFN-inducible genes were efficiently up-regulated. Alterations in TRAIL promoter sequence and activity were ...
Ezell SA, Tsichlis PN (2012) Akt1, EMSY, BRCA2 and type I IFN signaling: a novel arm of the IFN response. Transcription 3(6):305–309 CentralEzell SA, Tsichlis PN. Akt1, EMSY, BRCA2 and type I IFN signaling: a novel arm of the IFN response. Transcription. 2012; 3(6):305-9...
A. et al. IFN-λ4 attenuates antiviral responses by enhancing negative regulation of IFN signaling. J. Immunol. 199, 3808–3820 (2017). Article CAS PubMed Google Scholar Ramamurthy, N. et al. Impact of interferon lamda 4 genotype on interferon-stimulated gene expression during DAA therapy ...
Akt1, EMSY, BRCA2 and type I IFN signaling: a novel arm of the IFN response. Transcription. 2012; 3(6):305-9. doi: 10.4161/trns.21904 PMID: ... SA Ezell,PN Tsichlis 被引量: 7发表: 2012年 The protein kinase Akt1 regulates the interferon response through phosphorylation of the transc...
Two members of type II IFNs have been identified in fish, i.e. an IFN-gamma gene as in other vertebrates and a unique IFN-gamma related (IFN-gamma rel) gen... Zebrafish,TI Interferon,G Motif,... 被引量: 0发表: 0年 A type I interferon signaling factor, ISF21, encoded on chromoso...