Type I IFN signaling limits hemorrhage-like disease after infection with Japanese encephalitis virus through modulating a prerequisite infection of CD11b+Ly-6C+monocytesType I IFNJapanese encephalitisMonocytesHemorrhagic diseaseCytokine stormThe crucial role of type I interferon (IFN-I, IFN-伪/尾) is ...
The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections
Deletion of type I IFN genes and resistance to apoptosis induced by type I IFNs are common in glioblastoma. Here we have investigated the importance of the constitutive weak IFN-signaling in the apoptotic response to IFN-α in glioblastoma cells. U87MG cells hold a deletion of type I IFN ge...
2b). On the contrary, the vast majority of clones deficient in the IFN-I pathway presented a certain degree of impairment of ICD–CSC enrichment (Fig. 2b), indicating dependence on IFN-I signaling. This effect was not paralleled by differential cell death induction, as all clones displayed ...
Virus-induced type I IFN signaling pathways are tightly controlled by ubiquitination and deubiquitination. Several ubiquitin ligase enzymes have been identified to regulate these processes [28-35]. However, only a few DUBs are known to regulate these pathways: A20 was shown to negatively regulate ...
IFN (Type I/III) Signaling Pathway Antibody Sampler Kit 更多供应商 赛信通(上海)生物试剂有限公司 联系电话: 21-80243558 86218024 产品介绍: 英文名称:IFN (Type I/III) Signaling Pathway Antibody Sampler Kit 基本信息 中文名称IFN (Type I/III) Signaling Pathway Antibody Sampler Kit ...
ANOVA, analysis of variance; IHC, immunohistochemistry; IL-15, interleukin-15; IFN, interferon; RV, rhinovirus. PowerPoint slide IL-15c increased IL-15 and type I and type II IFN responses To determine which IL-15-stimulated responses do not require type I IFN signaling during RV infection,...
HEK-Blue™ IFN-α/β cellswere generated by stable transfection with the genes encoding humanSTAT2 andIRF9to obtain a fully active type I IFN signaling pathway. The other genes of the pathway (IFNAR1, IFNAR2, JAK1, TyK2, and STAT1) are naturally expressed by these cells. HEK-Blue™...
Depletion of either LRRC25 or ISG15 abrogates RIG-I-p62 interaction as well as the autophagic degradation of RIG-I. Collectively, our findings identify a previously unrecognized role of LRRC25 in type I IFN signaling activation by which LRRC25 acts as a secondary receptor to assist RIG-I ...
(IFNAR1 À / À ) mice have deficient type I and type III IFN production and NK-cell responses during RV infection; however, IL-15 expression was not assessed.10 There- fore, we used these mice to determine whether type I IFN signaling was required for IL-15 expression during RV ...