Type I IFN signaling limits hemorrhage-like disease after infection with Japanese encephalitis virus through modulating a prerequisite infection of CD11b+Ly-6C+monocytesType I IFNJapanese encephalitisMonocytesHemorrhagic diseaseCytokine stormThe crucial role of type I interferon (IFN-I, IFN-伪/尾) is ...
Result 1 - Identification of USP38 as an Essential Negative Regulator of Type I IFN Signaling Summary中提到: Here we report that USP38 negatively regulates type I IFN signaling by targeting the active form of TBK1 for degradation in vitro and in vivo. 那么,Result 1就是要确认USP38识别是一个...
The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections
Two members of type II IFNs have been identified in fish, i.e. an IFN-gamma gene as in other vertebrates and a unique IFN-gamma related (IFN-gamma rel) gen... Zebrafish,TI Interferon,G Motif,... 被引量: 0发表: 0年 A type I interferon signaling factor, ISF21, encoded on chromoso...
Type I interferon receptor signaling in donor T and hematopoietic cells does not contribute to the development of GVHD First, we addressed the influence of IFN-I on transplanted donor cells. To this end, we used a major mismatch allo-HSCT mouse model and administered allogeneic bone marrow (BM...
Depletion of either LRRC25 or ISG15 abrogates RIG-I-p62 interaction as well as the autophagic degradation of RIG-I. Collectively, our findings identify a previously unrecognized role of LRRC25 in type I IFN signaling activation by which LRRC25 acts as a secondary receptor to assist RIG-I ...
2b). On the contrary, the vast majority of clones deficient in the IFN-I pathway presented a certain degree of impairment of ICD–CSC enrichment (Fig. 2b), indicating dependence on IFN-I signaling. This effect was not paralleled by differential cell death induction, as all clones displayed ...
Type I IFNs (IFN-I) signaling is essential for innate anti-infection response by binding to IFN-α/β receptor (IFNAR). In this study, we infected WT mice and IFNAR-deficient A6 mice with herpes simplex virus 1 (HSV-1) via periocular injection to investigate the relationship between IFN-...
Moreover, BMM displayed enhanced basal mRNA levels, relative to GM-BMM, of a number of genes identified as being dependent on type I IFN signaling, including Stat1, Stat2, Irf7, Ccl5, Ccl12, and Cxcl10. As a result of prior type I IFN "priming," upon LPS stimulation BMM displayed ...
Virus-induced type I IFN signaling pathways are tightly controlled by ubiquitination and deubiquitination. Several ubiquitin ligase enzymes have been identified to regulate these processes [28-35]. However, only a few DUBs are known to regulate these pathways: A20 was shown to negatively regulate ...