Here, we identified that integrin-linked kinase (ILK) is a novel enhancing factor for DENV infection by suppressing type I interferon (IFN) responses. Mechanistically, ILK binds DENV NS1 and NS3, activates Akt and Erk, and induces NF-魏B-driven suppressor of cytokine signaling 3 (SOCS3) ...
We sought to determine whether the E3 ubiquitin ligase activity of PJA2 contributes to its negative regulation of type I IFN signaling. In an orthogonal approach to our siRNA-based depletion and KO studies, we found that overexpression of wild-type (WT) Flag-tagged PJA2 led to a dose-depend...
Type I interferon (IFN-I) mediated innate immune response controls virus infections by inducing the expression of interferon stimulated genes (ISGs). Although ubiquitination plays key roles in immune signaling regulation, a human genome-wide understanding of the role of E3 ubiquitin ligases in interfer...
摘要: LcSOCS3 contains typical SOCS domain architecture and is induced by Poly(I:C).LcSOCS3 promotes SVCV replication through inhibiting type I IFN signaling.LcSOCS3 regulates the type I IFN response by binding to STAT1.关键词:Antiviral response Interferon signaling Large yellow croaker SOCS3 ...
Viral infection activates Toll-like receptor and RIG-I (retinoic acid-inducible gene I) signaling pathways, leading to phosphorylation of IRF3 (interferon regulatory factor 3) and IRF7 and stimulation of type I interferon (IFN) transcription, a process important for innate immunity. We show that ...
More recently, TRIM9 was identified as a positive regulator in type I IFN signaling in antiviral immunity, which serves to balance pro-inflammatory responses and the production of type I IFNs [11]. These studies indicate that TRIM9 plays an important role in the regulation of innate immunity....
isproperly cited. Toll-likereceptor(TLR)signalingpathwaysarestrictlycoordinatedbyseveralmechanismstoregulateadequateinnateimmune responses.Recentlinesofevidenceindicatethatthesuppressorofcytokinesignaling(SOCS)familyproteins,originallyidentified asnegative-feedbackregulatorsincytokinesignaling,areinvolvedintheregulationof...
We therefore sought to define the involvement of A20 in the regulation of RIG-I signaling. Activation of the IFN antiviral state by RIG-I was completely inhibited by A20 expression, and the C-terminal zinc finger domain of the ubiquitin ligase region was required for the inhibitory function of...
Moreover, infection reduces the abundance of JAK-1 and tyrosine-phosphorylated JAK-1. Thus, the distinctive down-regulation of IFN- signaling by M. tuberculosis occurs together with a previously undescribed combination of inhibitory intracellular events. 展开 关键词: IFN-,Signaling ...
7, 8 This barrier is sufficient to inhibit the migration of immune cells from the circulation into the eye.9 Also, it allows the eye to bathe its own cells with molecules needed for metabolism, neuroretinal function, regulation of intraocular pressure, and the accumulation of anti-inflammatory ...