negative regulationtype I interferonType I IFNs (伪,尾, and others) are a family of cytokines that are produced in physiological conditions as well as in response to the activation of pattern recognition receptors
Type I interferon (IFN-I) mediated innate immune response controls virus infections by inducing the expression of interferon stimulated genes (ISGs). Although ubiquitination plays key roles in immune signaling regulation, a human genome-wide understanding of the role of E3 ubiquitin ligases in interfer...
3. Negative regulation of TLR signaling 3.1. Negative regulation of TLR signaling pathways by degradation In general, degradation or destabilization of signal transduction factors is one of the principal mechanisms that reduces or terminates the activation of signaling pathways. This type of mechanism oc...
Negative regulation of the type I IFN pathway involves numerous protein factors that act to limit PRRs, PRR signaling, and as well as IFN signaling itself. Suppressor of cytokine signaling (SOCS1 and SOCS3) proteins, specifically SOCS1 is a potent negative regulator of type I IFN signaling ...
1. Regulation of immune balance 2. Ubiquitin-mediated immune regulation 3. The tripartite motif (TRIM) E3 ligase family 4. TRIM family evolution 5. TRIM spatial regulation and cell-type specific expression 6. The IFN system 7. TRIM-mediated regulation of cytokine induction and signaling 8. Conc...
Upregulation of transcripts of IL1RL1 (ST2L) and SIGIRR of the TIR superfamily, may also modulate TLR signaling in diabetic tissues (Fig. 3b). Upregulation of IL1RL1 and SIGIRR was consistent with lower protein levels of MyD88, TLR4, IRAK4 and TRAF6 in diabetic 592 J Mol Med (2013) ...
3. Negative regulation of TLR signaling 3.1. Negative regulation of TLR signaling pathways by degradation In general, degradation or destabilization of signal transduction factors is one of the principal mechanisms that reduces or terminates the activation of signaling pathways. This type of mechanism ...
Taken together, our data suggest that the direct interaction between ICAM-1 and EGFR increases EGFR activity and downstream signaling Kang et al. Molecular Cancer (2024) 23:230 Page 4 of 18 Fig. 1 Upregulation of ICAM-1 Correlates with Poor Prognosis and Metastasis of ...
signalling; (3) basal-like immune-suppressed (BLIS) subtype characterized by upregulation of cell cycle processes, activation of DNA repair mechanisms, and downregulation of immune response genes; and (4) mesenchymal-like (MES) subtype characterized by upregulation of the JAK/STAT3 signalling ...
In addition to transcriptional regulation of antiviral genes, ubiquitinated IRF3 can induce RLH-induced IRF3-mediated pathway of apoptosis (RIPA) to protect the host from lethal viral infection [31]. Thus, manipulation of RLH signaling by ubiquitination is a common and critical means of both ...