In the present study, we investigated the role of type I Interferon (IFN-I) signaling in chronic unpredictable stress (CUS)-induced synapse loss and behavior deficits in mice. We found increased expression of type I IFN receptor (IFNAR) in microglia following CUS. Conditional knockout of ...
Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. In the present study, we show that type 1 interferon (IFN-I) regulates coinhibito
在机体对抗病原体入侵和肿瘤细胞产生的免疫防御体系中,Type I Interferon(I 型干扰素)信号通路宛如一座坚固的堡垒,而其相关蛋白则是这座堡垒中的核心战士,守护着机体的健康与稳定。I 型干扰素包括 IFN-α、IFN-β 等多种亚型,它们通过与细胞表面受体结合,激活复杂的信号传导网络,调控众多基因的表达,从而发挥强大的...
Based on analysis of cytokine expression profiles, type I interferon (IFN) mRNA is induced in host mouse livers at 1 hour post-injection. This type I IFN signaling amplifies cytokine expression in liver independent of the nature of vector DNA sequences after 3 hours post-injection. This type ...
Interleukin-15 (IL-15) is a type I interferon (IFN)-induced cytokine that exerts antiviral effects by activation of NK cells and CD8+ T cells.11, 12 IL-15 shares the IL-2Rβ- and common γ-chains of the IL-2 receptor,13, 14 but also binds its specific IL-15Rα-chain with much...
aInterestingly, within the IR gene set, increased expression of genes that are closely linked to Type 1 interferon (IFN) signalling was observed. 有趣的是,在与第一类型干扰素严密连接(基因之内的IR基因集合,增加的表示IFN)发信号被观察了。[translate]...
4. Li K. et al., 2005. Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. J Biol Chem. 280(17):16739-47. 5. Perry AK. et al., 2005. The host Type I interferon response to viral and bacterial infections. Cell Res 15:407...
In this study, we investigated the role of miR-744 in type I interferon (IFN) signaling pathway in primary human RMCs. We show that overexpression of miR-744 enhances IFN-induced CCL2, CCL5, CXCL10, and IL6 expression specifically in RMCs. We found that the activation of TYK2, STAT1 ...
A. et al. Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2. J. Biol. Chem. 286, 33811–33818 (2011). Article CAS PubMed PubMed Central Google Scholar Ho, H. H. & Ivashkiv...
ANOVA, analysis of variance; IHC, immunohistochemistry; IL-15, interleukin-15; IFN, interferon; RV, rhinovirus. MucosalImmunology | VOLUME 7 NUMBER 5 | SEPTEMBER 2014 1155 ARTICLES Figure 4 Rhinovirus-induced NK-cell responses were dependent on IL-15 signaling. BALB/c mice were either infected...