Lu J,Yi L,Ke C,et al.The interaction between human enteroviruses and type I IFN signaling path way [J].Crit Rev Microbiol,2015,41(2):201-207.摇Lu J, Yi L, Ke C, et al. The interaction between human enteroviruses and type I IFN signaling pathway [ J ] . Crit Rev Microbiol,...
et al. Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-γ-independent pathway. J. Immunol. 173, 1266–1275 (2004). CAS PubMed Google Scholar Gold, J. A. et al. Exogenous γ and α/β interferon rescues human macrophages from cell death ...
In this study, we revealed that type 1 IFNs are induced by activation of the TLR4–TRIF pathway in gastric epithelial cells after H. suis infection and can induce the production of IFN-γ from gastric B cells via an interaction between type 1 IFNs and type 1 IFN receptors (IFNARs). ...
Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J. Immunol. 178, 6705–6709 (2007). Article CAS PubMed Google Scholar Wang, X., Chen, M., Wandinger, K. P., Williams, G. & Dhib-Jalbut, S. IFN-β-1b ...
Additionally, these type 1 IFNs interact with type 1 IFN receptors on gastric B cells, facilitating the secretion of IFN-γ and the activation of which is enhanced by positive feedback regulation in B cells. These results suggest that the TLR4-TRIF-type 1 IFN-IFN-γ pathway is crucial in...
HEK-Blue™ IFN-α/β cellswere generated by stable transfection with the genes encoding humanSTAT2 andIRF9to obtain a fully active type I IFN signaling pathway. The other genes of the pathway (IFNAR1, IFNAR2, JAK1, TyK2, and STAT1) are naturally expressed by these cells. HEK-Blue™...
In contrast, expression of the NF-κB-regulated cytokines IL-6 and IL-1β was unaffected in IFI16 knockdown cells, suggesting that the role of IFI16 in sensing these triggers was unique to the type I IFN pathway. Surprisingly, we also found that knockdown of IFI16 led to a severe ...
Finally, miR-744 expression was induced by type I IFN in RMCs. Collectively, our data indicate that by targeting PTP1B, miR-744 plays a feed-forward role in regulating type I IFN signaling pathway. These findings give us new insights into the functions of renal miRNAs in regulating ...
[摘要] Ⅰ型干扰素通路病是一类由单基因突变引起的自身炎症性疾病,其特征是Ⅰ型干扰素信号通路异常激活,导致广泛的全身性炎症反应。在日常自身免疫性疾病诊疗中,早期识别这类疾病至关重要。对于起病年龄小、多系统炎症表现及自身抗体阳性的患者,临床医师应高度警惕Ⅰ
Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that activates the IFN pathway. Upon binding to DNA, cGAS is activated to catalyze ... Daxing,Gao,Tuo,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 85发表: 2015年 Act...