A new type I IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells. Stem Cells. 2003;21(3):357–62.Santini SM, Di Pucchio T, Lapenta C, Parlato S, Logozzi M, Belardelli F. A new type I IFN-mediated pathway for the rapid differentiation ...
Additionally, these type 1 IFNs interact with type 1 IFN receptors on gastric B cells, facilitating the secretion of IFN-γ and the activation of which is enhanced by positive feedback regulation in B cells. These results suggest that the TLR4-TRIF-type 1 IFN-IFN-γ pathway is crucial in...
In this study, we revealed that type 1 IFNs are induced by activation of the TLR4–TRIF pathway in gastric epithelial cells after H. suis infection and can induce the production of IFN-γ from gastric B cells via an interaction between type 1 IFNs and type 1 IFN receptors (IFNARs). ...
Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J. Immunol. 178, 6705–6709 (2007). Article CAS PubMed Google Scholar Wang, X., Chen, M., Wandinger, K. P., Williams, G. & Dhib-Jalbut, S. IFN-β-1b ...
Fig 4a:为了探究MitoStress的促炎功能,作者对MitoStress和MitoCo刺激的内皮进行了RNAseq检测。KEGG和GO富集分析结果显示和MitoCo相比,MitoStress刺激的内皮显著富集到I型 IFN 和 TNF 信号通路。 Fig 4b:从144个差异基因中,作者选择了10个此前报道的这两个pathway中的基因。包括OAS2, MX1, IFIT1, RSAD2, CCL...
Type I interferon (IFN) signalling uses a dual mechanism of action. A Jak-Stat pathway extensively described in mammals involves a cascade of reactions from the interaction of the IFN molecule with its membrane receptor to the stimulation of IFN-induced gene promoters leading in turn to an antiv...
et al. DENV inhibits type I IFN production in infected cells by cleaving human STING. PLoS Pathog. 8, e1002934 (2012). Article PubMed PubMed Central Google Scholar Ma, Z. & Damania, B. The cGAS-STING defense pathway and its counteraction by viruses. Cell Host Microbe 19, 150–158 ...
类似的,缺乏I型IFN受体的 Ifnar−/−鼠同样在MI后没有出现显著的I型干扰素反应的活化。 Taken together, these results are consistent with the concept that the cytosolic-DNA-sensing pathway is responsible for induction of an IRF3-dependent type I IFN response in the heart after MI; however, other...
In contrast, expression of the NF-κB-regulated cytokines IL-6 and IL-1β was unaffected in IFI16 knockdown cells, suggesting that the role of IFI16 in sensing these triggers was unique to the type I IFN pathway. Surprisingly, we also found that knockdown of IFI16 led to a severe ...
CD8 T Cells and Type I IFNs Sustains Protective Response in the Absence of IL12p40 目的 探讨吡罗昔康提高γδT细胞杀伤胃癌细胞的作用机理.方法 按常规方法培养γδT细胞,以不同浓度吡罗昔康诱导,收集培养上清液用于细胞因子IFN-γ,TNF-α,IL-12检测,... NN Orgun,MA Mathis 被引量: 0发表: 0年 ...