Disruption of type-I IFN pathway ameliorates preservation damage in mouse orthotopic liver transplantation via HO-1 dependent mechanism. Am J Transplant 2012; 12: 1730-1739.Shen XD, Ke B, Ji H, Gao F, Freitas MC, Chang WW, et al. Disruption of Type-I IFN pathway ameliorates preservation ...
In this study, we revealed that type 1 IFNs are induced by activation of the TLR4–TRIF pathway in gastric epithelial cells after H. suis infection and can induce the production of IFN-γ from gastric B cells via an interaction between type 1 IFNs and type 1 IFN receptors (IFNARs). ...
Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J. Immunol. 178, 6705–6709 (2007). Article CAS PubMed Google Scholar Wang, X., Chen, M., Wandinger, K. P., Williams, G. & Dhib-Jalbut, S. IFN-β-1b ...
The most studied members of the Type I family of interferons are the multiple IFNα isotypes and IFNβ. Type I IFNs are responsible for inducing transcription of a large group of genes which play a role in host resistance to viral infections
Type I interferon-mediated pathway interacts with peroxisome proliferator activated receptor-γ (PPAR-γ): At the cross-road of pancreatic cancer cell prol... Type I interferon-mediated pathway interacts with peroxisome proliferator activated receptor-γ (PPAR-γ): At the cross-road of pancreatic ...
In this study, we investigated the role of miR-744 in type I interferon (IFN) signaling pathway in primary human RMCs. We show that overexpression of miR-744 enhances IFN-induced CCL2, CCL5, CXCL10, and IL6 expression specifically in RMCs. We found that the activation of TYK2, STAT1 ...
In contrast, expression of the NF-κB-regulated cytokines IL-6 and IL-1β was unaffected in IFI16 knockdown cells, suggesting that the role of IFI16 in sensing these triggers was unique to the type I IFN pathway. Surprisingly, we also found that knockdown of IFI16 led to a severe ...
类似的,缺乏I型IFN受体的 Ifnar−/−鼠同样在MI后没有出现显著的I型干扰素反应的活化。 Taken together, these results are consistent with the concept that the cytosolic-DNA-sensing pathway is responsible for induction of an IRF3-dependent type I IFN response in the heart after MI; however, other...
Here we report that USP38 negatively regulates type I IFN signaling by targeting the active form of TBK1 for degradation in vitro and in vivo. 那么,Result 1就是要确认USP38识别是一个重要的负调节I型干扰素的信号。 为了确定去泛素化酶在抗病毒免疫性中的角色,研究者运用生物信息学方法进行了数据分析...
These include the well-studied canonical Jak-Stat pathway, largely responsible for the antiviral and growth-inhibitory activities of IFNs, as well as the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways, whose importance in IFN-induced biologic outcomes has ...