Disruption of Type-I IFN pathway ameliorates preservation damage in mouse orthotopic liver transplantation via HO-1 dependent mechanism. Am J Transplant. 2012; 12: 1730-1739.X. D. Shen, B. Ke, H. Ji et al., "Disruption of type-I IFN pathway ameliorates preservation damage in mouse ...
Type I IFNs trigger antiviral responses by binding to a common receptor (IFNAR). IFNα/β binding to IFNAR stimulates the JAK1-STAT pathway leading to the assembly of the ISGF3 complex which is composed of STAT1-STAT2 dimers and IRF9. ISGF3 binds to IFN-stimulated response elements (ISRE...
Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J. Immunol. 178, 6705–6709 (2007). Article CAS PubMed Google Scholar Wang, X., Chen, M., Wandinger, K. P., Williams, G. & Dhib-Jalbut, S. IFN-β-1b ...
In this study, we revealed that type 1 IFNs are induced by activation of the TLR4–TRIF pathway in gastric epithelial cells after H. suis infection and can induce the production of IFN-γ from gastric B cells via an interaction between type 1 IFNs and type 1 IFN receptors (IFNARs). ...
As IFN-I plays a role during ICD11, we asked whether immunogenic chemotherapy could enrich for CSCs. We took advantage of a library of prevalidated MCA205-derived clones deficient for cardinal elements of the IFN-I pathway, including: (1)Ifnar1, (2) stimulator of interferon response cGAMP ...
Our findings provide insight into how the type I IFN signaling pathway may play a role regulate IL-2 expression in CD4⁺ T cells. 展开 关键词: Interferon Type I CD4-Positive T-Lymphocytes Receptors, Interleukin-2 Thesis 年份: 2013
类似的,缺乏I型IFN受体的 Ifnar−/−鼠同样在MI后没有出现显著的I型干扰素反应的活化。 Taken together, these results are consistent with the concept that the cytosolic-DNA-sensing pathway is responsible for induction of an IRF3-dependent type I IFN response in the heart after MI; however, other...
Fig 4a:为了探究MitoStress的促炎功能,作者对MitoStress和MitoCo刺激的内皮进行了RNAseq检测。KEGG和GO富集分析结果显示和MitoCo相比,MitoStress刺激的内皮显著富集到I型 IFN 和 TNF 信号通路。 Fig 4b:从144个差异基因中,作者选择了10个此前报道的这两个pathway中的基因。包括OAS2, MX1, IFIT1, RSAD2, CCL...
A detailed understanding of the factors controlling type I IFN gene transcription will significantly aid in the identification and development of new therapeutic strategies targeting the IFN pathway in autoimmune disease. 展开 关键词: type I interferons bioinformatics autoimmunity transcriptional regulation ...
Deletion of type I IFN genes and resistance to apoptosis induced by type I IFNs are common in glioblastoma. Here we have investigated the importance of the constitutive weak IFN-signaling in the apoptotic response to IFN-α in glioblastoma cells. U87MG cells hold a deletion of type I IFN ge...