所谓T细胞耗竭(T Cell Exhaustion)就是指常见慢性感染和癌症患者体内T细胞功能丧失。由于长期暴露于持续性抗原或慢性炎症,疲惫的T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。不过这种耗竭是可以逆转的,至少部分逆转,主要是通过阻止PD-1之类的抑制性通路。 TEx Are a...
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性...
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents ...
所谓T细胞耗竭(T Cell Exhaustion),指的是常见于慢性感染和癌症患者体内T细胞功能丧失的一种现象 由于长期暴露于持续性抗原和炎症,精疲力竭的T细胞逐渐失去效应功能,这种耗竭是可逆转的 当遭受慢性感染时...
‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours. Understanding the features of and pathw
et al.LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion.Nat Genet54, 180–193 (2022). doi.org/10.1038/s41588- 摘要:基因表达如何被控制以维持人类T细胞的静止状态还知之甚少。在这里,我们展示了含有 Long Interspersed Nuclear Element 1(LINE1,长散布核...
Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion, which is characterized by reduced effector function and proliferation, and the expression of inhibitory immune checkpoint receptors. Recent studies have demonstrated that T cell exhaustion results in wholescale epi...
Laboratory tests and the level of gene expressions related to 4 inhibitory co-receptors, including LAG-3, TIM-3, TIGIT, PD-1, and T-bet and Eomes transcription factors involved in the process of Tcell exhaustion in severe and mild patients of Covid-19 were investigated. The results showed...
CD8+ T-cell exhaustion in cancer: mechanisms and new area for cancer immunotherapy. Immunotherapies have emerged as the most promising area in cancer treatments in recent years. CD8~+ T cells, as one of the primary effector cells of antica... QF He,Y Xu,J Li,... - Brief Funct Genomics...
[74,75]. To characterize tumor microenvironment of bone metastasis of prostate cancer, Kfoury et al. performed single-cell analysis and found bone marrow infiltration of tumor-associated macrophages and monocytes with overexpression of cytokine CCL2, leading to T-cell exhaustion as a mechanism of ...