Hence, it is important to gain insight into the potential role of T cell depletion in the tumor microenvironment. The purpose of this study was to develop a trustworthy TEX-based signature using single-cell RNA-seq (scRNAseq) and high-throughput RNA sequencing, opening up new...
所谓T细胞耗竭(T Cell Exhaustion)就是指常见慢性感染和癌症患者体内T细胞功能丧失。由于长期暴露于持续性抗原或慢性炎症,疲惫的T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。不过这种耗竭是可以逆转的,至少部分逆转,主要是通过阻止PD-1之类的抑制性通路。 TEx Are a...
‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours. Understanding the features of and pathw
Furthermore, single cell RNA sequencing of CD19 CAR T infusion product also showed enrichment of exhaustion signature in patients with partial response or progressive disease compared to those with complete response [22]. These observations suggest that CAR T cell exhaustion is one of the major ...
Molecular and cellular insights into T cell exhaustion. Nat. Rev. Immunol. 15, 486–499 (2015). Article CAS PubMed PubMed Central Google Scholar Tauriello, D. V. F. et al. TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis. Nature 554, 538–543 (2018). ...
P4HA1; T cell memory; T cell exhaustion; mitochondria; systemic immunity; hypoxia; PD-1; CAR T cells; solid tumors; cancer immunotherapy Introduction Para_01 目前的癌症免疫疗法,包括免疫检查点阻断(ICB)和过继细胞疗法(ACT),例如嵌合抗原受体T(CAR T)细胞疗法,在癌症治疗中展现了巨大的潜力。
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性...
11. Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, Wang Q, Yang M, Kalady MF, Qian J, Zhang A, Gupte AA, Hamilton DJ, Zheng C, Yi Q. Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment. Cell Metab. 2019 Jul 2; 30(1):143-156.e5. doi: 10.1016/j.cmet...
11. Ma X, Bi E, Lu Y, Su P, Huang C, Liu L, Wang Q, Yang M, Kalady MF, Qian J, Zhang A, Gupte AA, Hamilton DJ, Zheng C, Yi Q. Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment. Cell Metab. 2019 Jul 2; 30(1):143-156.e5. doi: 10.1016/j.cmet...
英文名称: T Cell Exhaustion Marker (PD1, CTLA4, TIM3, LAG3, TIGIT) Antibody Panel - Human, IHC 英文同义词: T Cell Exhaustion Marker (PD1, CTLA4, TIM3, LAG3, TIGIT) Antibody Panel - Human, IHC CAS号: 分子式: 分子量: 0 EINECS号: 信息错误报告 您的Email: 按...