‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours. Understanding the features of and pathw
CD8(+) T cell exhaustion (TEX) impairs the ability of T cells to clear chronic infection or cancer. While T-EX are hypofunctional, some TEX retain effector... SE Mcclory,O Bardhan,Rome, Kelly S.Giles, Josephine R.Baxter, Amy E.Xu, LanweiGimotty, Phyllis A.Faryabi, Robert B.Wherry...
Conclusion:Our results offer novel insights on the impact of culture duration on the acquisition of T-cell exhaustion features. Using a new clinical-compliant protocol, we define critical parameters to monitor in order to optimally differentiate and expand MiHA-specific T cells in culture prior to ...
However, the efficacy of the transferred cells is hampered by the acquisition of terminal effector differentiation and exhaustion features during expansion in vitro thus preventing their function and persistence in vivo. Yet, the factors that induce T-cell differentiation and functional impairment in ...
However, the efficacy of the transferred cells is hampered by the acquisition of terminal effector differentiation and exhaustion features during expansion in vitro thus preventing their function and persistence in vivo. Yet, the factors that induce T-cell differentiation and functional impairment in ...
Functional exhaustion of antiviral lymphocytes in COVID-19 patients. Cell. Mol. Immunol. 17, 533–535 (2020). CAS PubMed PubMed Central Google Scholar Witkowski, M. et al. Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells. Nature 600, 295–301 (2021). CAS ...
(MiHA)-specific T cells is a promising therapy forpatients with hematological cancers. However, the efficacy of the transferred cells is hampered by the acquisition ofterminal effector differentiation and exhaustion features during expansion in vitro thus preventing their functionand persistence in vivo....
1A). In order to overexpress RAV1 and RAV2, yeast cells were grown in low glucose media until glucose exhaustion. Galactose was then added, and cells underwent one doubling before growth arrest. As shown in Figure 1B, this strategy yielded a significant increase in levels of the ∼150 ...
(Biosen S-line EKFDiagnostics, Barleben, Germany). The participants were asked to reach maximal volitional exhaustion at the end of CPX. Termination criteria for CPX were cadence < 70/min in bicycle ergometry, leaving a predefined running zone on the treadmill, occurring symptoms such as ...
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