所谓T细胞耗竭(T Cell Exhaustion)就是指常见慢性感染和癌症患者体内T细胞功能丧失。由于长期暴露于持续性抗原或慢性炎症,疲惫的T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。不过这种耗竭是可以逆转的,至少部分逆转,主要是通过阻止PD-1之类的抑制性通路。 TEx Are a...
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性...
T Cell Exhaustion | Cell and Cytokine Profiling T-cell exhaustion is a broad term used to describe T cell dysfunction resulting from chronic stimulation. Exhausted T cells present with a distinct phenotype including overexpression of inhibitory markers such as PD-1, LAG-3 and TIM-3 as well as...
5. Zhang Y, Trang V, Palmer DC, Kishton RJ, Gong L, Huang J, Nguyen T, Chen Z, Smith C, Livák F, Paul R, Day CP, Wu C, Merlino G, Aldape K, Guan XY, Jiang P. A T cell resilience model associated with response to immunotherapy in multiple tumor types. Nat Med. 2022 May...
T cell exhaustion. Nat Immunol 12:492- 499.Wherry EJ (2011) T cell exhaustion. Nat Immunol 12(6):492–499 PubMedWherry EJ. 2011. T cell exhaustion. Nat. Immunol. 131:492- 499.Wherry EJ. T cell exhaustion[J]. Nat Immunol, 2011, 12(6): 492-499. ( 责任编辑:潘慧敏 )...
T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine pr
A Human In Vitro T Cell Exhaustion Model for Assessing Immuno-Oncology Therapies. (Springer, 2020). 】 (3)补充信息T细胞治疗 : 用5 µg/mL 放线菌素D(Merck;目录号 A9415)处理naive CD4+ T细胞16h,如2述。 使用下列免疫抑制药物进行TCR信号通路抑制: Rapamycin雷帕霉素(100 nM;Merck; cat. num...
这篇综述聚焦 T 细胞衰老(senescence)与耗竭(exhaustion)。详细阐述其特征、机制及与疾病的关联,剖析二者区别与联系。对理解免疫系统功能、疾病发病机制意义重大,为精准免疫调节策略提供理论依据。 引言 T 细胞作为适应性免疫的关键效应细胞,通过细胞毒性介导的病原体清除(借助穿孔素和颗粒酶)以及细胞因子驱动的免疫调节...
Mechanisms and markers of T cell exhaustion Immune Checkpoint Receptors The onset of T cell exhaustion coincides with the surface expression of co-inhibitory receptors, which control CD8+T cell function. Such immune checkpoints, which include programmed cell death protein (PD-1), cytotoxic T lymphoc...
PD-1全名为 Cell Death protein,即细胞死亡蛋白1。PD-1通过以下途径在抑制免疫反应和促进自我耐受方面发挥着重要作用:①调节T细胞活性、②激活抗原特异性T细胞凋亡、③抑制调节性T细胞的凋亡。程序性细胞死亡配体1(PD-L1)是一种跨膜蛋白,被认为是免疫应答的共同抑制因子,它可以与PD-1结合以减少PD-1阳性细胞的增殖...