所谓T细胞耗竭(T Cell Exhaustion)就是指常见慢性感染和癌症患者体内T细胞功能丧失。由于长期暴露于持续性抗原或慢性炎症,疲惫的T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。不过这种耗竭是可以逆转的,至少部分逆转,主要是通过阻止PD-1之类的抑制性通路。 TEx Are a...
T cell exhaustion. Nat Immunol 12:492- 499.Wherry E J.T cell exhaustion.Nature Immunology. 2011Wherry E J. T cell exhaustion[J]. Nat Immunol,2011; 12 ( 6) : 492-499.Wherry EJ.T cell exhaustion[J].Nat Immunol,2011,12(6):492-499....
at 200K/well. Exhausted T cells had been repeatedly stimulated (5 times total, every 2-3 days) with Dynabeads CD3/CD28 (1:1 bead-to-cell ratio). In-well, activation was induced with Dynabeads CD3/CD28. Every 24h, 10uL samples were analysed using the iQue®Human T Cell Exhaustion Kit...
T-cellexhaustionwasfirstdescribedastheclonaldeletion ofvirus-specificCD8Tcellsthatoccursduringhigh- gradechronicinfections. 1 Technologicaladvancements, especiallytheproductionofmajorhistocompatibility complexmultimerswhichcanidentifyantigen-specificT cellswithoutrelyingonfunctionalreadouts,aswellasthe ...
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents...
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性...
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents...
Chimeric antigen receptor (CAR) T cell therapy has attracted attention for its promising therapeutic effects on hematological malignancies. However, there are problems such as relapse during long-term follow-up and limited effect on solid tumors with this therapy. Exhaustion, which impairs in vivo pe...
, 193.]. While CTLA-4 blockade reduces the activation threshold required for T-cell priming [164], PD1/PD-L1 blockade can reverse, at least in part and for some T-cell subsets [194, 195], immune defects such as exhaustion [196, 197], thus enabling synergy when the treatments are ...
T cells exhibit heterogeneous functional states in the tumor microenvironment. Immune checkpoint inhibitors (ICIs) can reinvigorate only the stem cell-like progenitor exhausted T cells, which suggests that inhibiting the exhaustion progress will improve