• Rahim et al. Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes;Cell. 2023 PubMed ID: 36931243[4] • Globig et al. The β1-adrenergic ...
Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection. J. Virol. 83, 4386–4394 (2009). CAS PubMed Central PubMed Google Scholar Brooks, D.G., Teyton, L., Oldstone, M.B. & McGavern, D.B. Intrinsic functional dysregulation of CD4 T cells...
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E. et al. T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion? Nat. Rev. Immunol. 14, 768–774 (2014). CAS PubMed Google Scholar Jin, X. et al. Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected ...
美国目前专门用于T细胞耗竭研究的课题共有2,568项(关键词:T Cell Exhaustion)。从2011的61项,一直到2022年的415项。 (美国国立卫生研究院基金资助的时间分布和项目数量) 2,论文质量和增速 到2022年11月5日,T细胞耗竭研究领域已经发...
In chronic infections and cancers, T lymphocytes (T cells) are exposed to persistent antigen or inflammatory signals. The condition is often associated with a decline in T-cell function: a state called “exhaustion”. T cell exhaustion is a state of T ce
Article CAS PubMed PubMed Central Google Scholar Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, Ingaramo M, et al. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med. 2015;21(6):581–90. Article CAS PubMed PubMed...
cell exhaustion and apoptosis [79]. Allogeneic CD19- specific CAR T cells- mediated anti-lymphoma activity without causing a significant increase in the incidence of graft-versus-host disease (GVHD) also suggests that both the TCR and CAR are engaged to accelerate T cells exhaustion [80]. CAR...
These data suggest that expression of molecular circuits related to chemotaxis, T cell activation, IFN signaling, and T cell exhaustion may help to identify patients that will benefit from CPI and allude to potential immunological networks involving neoantigen reactive T cells that may confer ...
et al. The epigenetic landscape of T cell exhaustion. Science 354, 1165–1169 (2016). This paper used ATAC–seq to define the chromatin accessibility landscape of exhausted CD8+ T cells in LCMV clone-13 infection, which was conserved in exhausted human T cells. Article CAS PubMed PubMed ...