所谓T细胞耗竭(T Cell Exhaustion)就是指常见慢性感染和癌症患者体内T细胞功能丧失。由于长期暴露于持续性抗原或慢性炎症,疲惫的T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。不过这种耗竭是可以逆转的,至少部分逆转,主要是通过阻止PD-1之类的抑制性通路。 TEx Are a...
Reversing this T cell exhaustion has been emerging as a "game-changing" therapeutic approach against cancer and chronic viral infection. Areas covered : This review discusses the cellular pathways related to T cells exhaustion, and the clinical development and possible cellular targets that can be ...
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性...
‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours. Understanding the features of and pathw
T Cell Exhaustion | Cell and Cytokine Profiling T-cell exhaustion is a broad term used to describe T cell dysfunction resulting from chronic stimulation. Exhausted T cells present with a distinct phenotype including overexpression of inhibitory markers such as PD-1, LAG-3 and TIM-3 as well as...
How metabolic stress affects T-cell exhaustion remains unclear; therefore, in this Review, we summarize current knowledge of how T-cell exhaustion occurs, and discuss how metabolic insufficiency and prolonged stress responses may affect signalling cascades and epigenetic reprogramming, thus locking T ...
这篇综述聚焦 T 细胞衰老(senescence)与耗竭(exhaustion)。详细阐述其特征、机制及与疾病的关联,剖析二者区别与联系。对理解免疫系统功能、疾病发病机制意义重大,为精准免疫调节策略提供理论依据。 引言 T 细胞作为适应性免疫的关键效应细胞,通过细胞毒性介导的病原体清除(借助穿孔素和颗粒酶)以及细胞因子驱动的免疫调节...
in dysfunctional T cells, driven by chronic T cell receptor stimulation and activation of transcription factors known as nuclear factor of activated T cells (NFATs). A strong and growing body of evidence has shown that TOX is involved in maintaining tumors and promoting T cell exhaustion. ...
LINE1以非经典转录本变体形式剪切来调控T细胞静止和耗竭状态《Nature Genetics》意大利米兰大学,IF: 41.307,中科院一区 Cite:Marasca, F., Sinha, S., Vadalà, R. et al.LINE1 are spliced in non-canonical t…
PD-1全名为 Cell Death protein,即细胞死亡蛋白1。PD-1通过以下途径在抑制免疫反应和促进自我耐受方面发挥着重要作用:①调节T细胞活性、②激活抗原特异性T细胞凋亡、③抑制调节性T细胞的凋亡。程序性细胞死亡配体1(PD-L1)是一种跨膜蛋白,被认为是免疫应答的共同抑制因子,它可以与PD-1结合以减少PD-1阳性细胞的增殖...