The Human Exhausted T Cell Antibody Sampler Kit provides an economical means of characterizing the extent of exhaustion in T cells. This kit includes enough antibodies to perform two western blot experiments with each primary antibody. Background Tox, TCF1/TCF7, and EOMES play key roles in ...
(Tpex) cells1. These precursors express TOX and PD-1, and have epigenetic and transcriptional profiles similar to those of exhausted T cells. We further show that these T cells are driven by strong TCR stimulation and that their development is promoted by ligand affinity and antagonized by PD...
DeTOXifying exhausted T cellsNFAT1‐induced TOX expression is necessary and sufficient for acquisition of features of CD8+ T cell exhaustion in settings of chronic antigen exposure such as chronic viral infection or cancer and helps prevent activation‐induced cell death....
Revitalization of exhausted CD8+ T cells is a major therapeutic opportunity for cancer and viral infections. As current knowledge of exhausted T cells mainly comes from chronic viral infection in mice, it is crucial to determine the requirements for effective T cell reinvigoration in humans. In ...
求翻译:exhausted T cells是什么意思?待解决 悬赏分:1 - 离问题结束还有 exhausted T cells问题补充:匿名 2013-05-23 12:21:38 疲惫的T细胞 匿名 2013-05-23 12:23:18 被用尽的T细胞 匿名 2013-05-23 12:24:58 被用尽的t淋巴细胞 匿名 2013-05-23 12:26:38 精疲力竭的 T 细胞 匿名...
those cells that are terminally exhausted tend not to respond to such therapy. “Response rates to immunotherapy in solid tumors remain low due in part to the elevated prevalence of terminally exhausted T cells, a hypofunctional differentiation state induced through persistent antigen and stress si...
4 reagents referenced in Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
Functional impairment of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To address this question, we analyzed genes expressed in functionally impaired virus-specific CD8 T cells present in ...
The battle between the human immune system and long-term, persisting infections and other chronic diseases such as cancer results in a prolonged stalemate. Over time battle-weary T cells become exhausted, giving germs or tumors an edge. Using data from m
T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as a bottle neck in the field of cancer immunotherapy have undoubtedly provoked attention. One of the main drivers of T cell ex...