求翻译:exhausted T cells是什么意思?待解决 悬赏分:1 - 离问题结束还有 exhausted T cells问题补充:匿名 2013-05-23 12:21:38 疲惫的T细胞 匿名 2013-05-23 12:23:18 被用尽的T细胞 匿名 2013-05-23 12:24:58 被用尽的t淋巴细胞 匿名 2013-05-23 12:26:38 精疲力竭的 T 细胞 匿名 ...
Moreover, the progenitor-like precursor cell population may be a subset of T cells that can respond to immunotherapy. Studies have also found that TOX initiates and dominates the development of exhausted T cells at the transcriptional and epigenetic levels. TOX also maintains T cell survival and ...
Exhausted T cells perk upMatthew A. Williams & Michael J. Bevan Nature volume 439, pages 669–670 (2006)Cite this article 1194 Accesses Metrics details During persistent infections, the immune cells responsible for killing infected cells and maintaining inflammation gradually stop functioning, allowing...
Revitalization of exhausted CD8+ T cells is a major therapeutic opportunity for cancer and viral infections. As current knowledge of exhausted T cells mainly comes from chronic viral infection in mice, it is crucial to determine the requirements for effective T cell reinvigoration in humans. In ...
Exhausted T cells are a group of dysfunctional T cells, which are present in chronic infections or tumors. The most significant characteristics of exhausted T cells are attenuated effector cytotoxicity, reduced cytokine production, and upregulation of multiple inhibitory molecular receptors(e.g., PD-...
Functional impairment of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To address this question, we analyzed genes expressed in functionally impaired virus-specific CD8 T cells present in ...
将CAR-T细胞和143B细胞按1:1的E:T (Effector:Target)比例接种于含有1x莫能菌素(EBioscience)和1ml CD107a抗体(Clone H4A3,BioLegend)的T细胞培养液(不添加IL-2)中5~6小时。孵育结束后,用FoxP3转录因子染色缓冲液进行细胞内细胞因子染色。 14、小鼠组织分析 ...
Knowing the intricate step-by-step process of T cell differentiation opens up more opportunities for immunologists to exploit them using cellular therapies. That could include, for example, rewiring T cells at one stage to "stop," so they don't advance to the next stage, or manipulating later...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswere
AR Lebeck,J Koppanalil,T Li,... - 《Acm Sigarch Computer Architecture News》 被引量: 414发表: 2002年 Continual flow pipelines Increased integration in the form of multiple processor cores on a single die, relatively constant die sizes, shrinking power envelopes, and emerging appli... ST Sri...