Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswere
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswered question is whether TEX cells differentiate...
Our study focused on exhaust CD8 + T cells (CD8 + Tex). The recent surge in cancer immunotherapy, primarily based on checkpoint blockade, has been a breakthrough in treating various cancer types. However, certain factors are hindering the progress of these treatments, such as varying ...
Wherry's lab has spent the last decade describing these populations of fatigued cells. Overall, when normal T cells become exhausted, they develop defects in their germ- and tumor-fighting capabilities. Tex also express inhibitory receptor proteins on their surface that stall key biochemical pathways...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswered question is whether TEX cells differentiate...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. ... MS Abdel-Hakeem,S Manne,JC Beltra,... - 《Nature...
TCF-1 mediated a T-bet-to-Eomes transcription factor transition in Tex precursors by promoting Eomes expression and drove c-Myb expression that controlled Bcl-2 and survival. These data define a role for TCF-1 in early-fate-bifurcation-driving Tex precursor cells and also identify PD-1 as a...
The dysfunction of these cells is thought to underlie the viral persistence seen in chronic infection. In murine LCMV or tumor models, in adaptation to persistent viral or tumor antigen stimulation, antigen-specific T cells undergo extensive molecular reprogramming into exhausted T (Tex) cells with ...
To directly measure EGR2 expression in chronic and acute LCMV infection, we examined EGR2 protein levels by flow cytometry within tetramer-stained H-2DbGP33-41-specific CD8+ T cells (GP33+ cells, Supplementary Fig. 1a) isolated from the spleens of C57BL/6 (B6) mice infected with either ...
The median OS for patients with high vs low Texstemwas 33.5 vs 11.1 months (HR 0.302, 95% CI 0.129 – 0.705, p = 0.006). In addition, there was also a positive association between Texstemto Textermratio and OS. Conversely, TextermCD8+ T cells did not impact OS in either cancer ...