Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswere
Our study focused on exhaust CD8 + T cells (CD8 + Tex). The recent surge in cancer immunotherapy, primarily based on checkpoint blockade, has been a breakthrough in treating various cancer types. However, certain factors are hindering the progress of these treatments, such as varying ...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswered question is whether TEX cells differentiate...
TCF-1 is a key transcription factor in progenitor exhausted CD8 Tcells (Tex). Moreover, this Tex cell subset mediates responses to PD-1 checkpoint pathway blockade. However, the role of the transcription factor TCF-1 in early fate decisions and initial generation of Tex cells is unclear. ...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswered question is whether TEX cells differentiate...
CD8(+) T cell exhaustion (TEX) impairs the ability of T cells to clear chronic infection or cancer. While T-EX are hypofunctional, some TEX retain effector... SE Mcclory,O Bardhan,Rome, Kelly S.Giles, Josephine R.Baxter, Amy E.Xu, LanweiGimotty, Phyllis A.Faryabi, Robert B.Wherry...
To directly measure EGR2 expression in chronic and acute LCMV infection, we examined EGR2 protein levels by flow cytometry within tetramer-stained H-2DbGP33-41-specific CD8+ T cells (GP33+ cells, Supplementary Fig. 1a) isolated from the spleens of C57BL/6 (B6) mice infected with either ...
However, other changes induced by RT, such as necrosis of tumor cells and release of tumor neoantigens, could recruit T cells, NKs, and NKTs from peripheral blood, which enhanced the antitumor property at that time point. However, clonal expansion of terminal exhausted CD8-Tex and pre-...
The median OS for patients with high vs low Texstemwas 33.5 vs 11.1 months (HR 0.302, 95% CI 0.129 – 0.705, p = 0.006). In addition, there was also a positive association between Texstemto Textermratio and OS. Conversely, TextermCD8+ T cells did not impact OS in either cancer ...
Exhausted CD8^(+)T(Tex)cells are dysfunctional due to persistent antigen exposure in chronic viral infection and tumor contexts.A stem cell-like Tex(Tex-stem)subset can self-renew and differentiate into terminally exhausted(Tex-term)cells.Here,we show that ectopic Tcf1 expression potently promoted...