complete reduction in T cell activation (complete loss of CD38, HLA-DR, ICOS, CD69 and CD71 expression), a switch toward a central memory phenotype with more cells expressing CCR7 and, especially, CD127, and a
叶丽林团队及Rafi Ahmed,Di Yu等研究团队在2016年分别独立发现, 慢性病毒感染中,位于淋巴组织内的耗竭程度较低的CXCR5+TCF-1+ Tim3-CD8+T细胞作为耗竭前体细胞(progenitor exhausted T cell, Tpex),功能性响应PD-1 ICB。Tpex的发现打破了将耗竭T细胞作为“Zombie”细胞的固有印象,并立即成为T细胞耗竭领域的研究热点...
4 single-cell sequence data sets were included as shown in Table1. This dataset comprises expression data from immune cells obtained through fluorescence-activated cell sorting (FACS), focusing on an enriched fraction of immune cells. The MAESTRO v1.1.0 workflow...
Nuclear ACSS2 overexpression or ACLY inhibition prevented TEX differentiation and enhanced tumor-specific T cell responses. These findings unveiled a nutrient-instructed histone code governing CD8 + T cell differentiation, with implications for metabolic- and epigenetic-based T cell therapies. 展开 ...
International Journal of Oral Science www.nature.com/ijos ARTICLE OPEN A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy Dikan Wang 1, Juan Fang1, Shuqiong Wen1...
英文名称 Human Exhausted T Cell Antibody Sampler Kit 英文同义词 Human Exhausted T Cell Antibody Sampler Kit CAS号 分子式 分子量 0 EINECS号 相关类别 Mol文件 Mol File 结构式 Human Exhausted T Cell Antibody Sampler Kit 性质 Human Exhausted T Cell Antibody Sampler Kit 用途与合成方法 安全信...
Hepatocellular carcinoma has a high incidence and poor prognosis. In this study, we investigated the value of T-cell-related genes in prognosis by single-cell sequencing data in hepatocellular carcinoma. Twelve cases of hepatocellular carcinoma single-ce
The Mouse Progenitor Exhausted CD8+ T Cell Markers Flow Cytometry Panel can be used to identify progenitor exhausted CD8+ T cells and their differentiated T cells with effector potential.Cytotoxic T cells are identified by co-expression of CD3 and CD8α. Among these ...
我们长期聚焦于生命科学、生物医药、医疗诊断、分析检测等领域,主要提供 包括抗体、重组蛋白、细胞因子、ELISA试剂盒、流式试剂、免疫组化试剂、生化试剂、分子生物学试剂、细胞系和细胞产品、科学仪器、耗材、LabEx(多因子实验服务)、产品订制服务、技术培训、软件和供应链等在内的生命科学一站式产品及服务,产品覆盖...