求翻译:exhausted T cells是什么意思?待解决 悬赏分:1 - 离问题结束还有 exhausted T cells问题补充:匿名 2013-05-23 12:21:38 疲惫的T细胞 匿名 2013-05-23 12:23:18 被用尽的T细胞 匿名 2013-05-23 12:24:58 被用尽的t淋巴细胞 匿名 2013-05-23 12:26:38 精疲力竭的 T 细胞 匿名 ...
T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as a bottle neck in the field of cancer immunotherapy have undoubtedly provoked attention. One of the main drivers of T cell ex...
Functional impairment of antigen-specific T cells is a defining characteristic of many chronic infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To address this question, we analyzed genes expressed in functionally impaired virus-specific CD8 T cells present in ...
During persistent infections, the immune cells responsible for killing infected cells and maintaining inflammation gradually stop functioning, allowing the pathogen to thrive. But can this process be reversed? This is a preview of subscription content, access via your institution Access options ...
As current knowledge of exhausted T cells mainly comes from chronic viral infection in mice, it is crucial to determine the requirements for effective T cell reinvigoration in humans. In humans, hepatitis C virus (HCV) infection can be naturally resolved and lead to memory T cell formation, or...
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8+ T cells during HIV infection...
In the mouse model of chronic Lymphocytic Choriomeningitis Virus infection, virus-specific CD8+T cells contain a population of CD39highCD8+T cells that is absent in functional memory cells elicited by acute infection. This CD39highCD8+T cell population is enriched for cells with the phenotypic ...
4 reagents referenced in Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
A decade ago researchers announced development of a cancer immunotherapy called CAR (for chimeric antigen receptor)-T, in which a patient is re-infused with their own genetically modified T cells equipped to mount a potent anti-tumor attack. Since then C