As current knowledge of exhausted T cells mainly comes from chronic viral infection in mice, it is crucial to determine the requirements for effective T cell reinvigoration in humans. In humans, hepatitis C virus (HCV) infection can be naturally resolved and lead to memory T cell formation, or...
T cell exhaustion limits effector T cell function in chronic infection and tumours1,2. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions that are met only after persistent exposure to antigen and inflammation. Here we show, howev...
4 reagents referenced in Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections.
During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed using immunotherapy drugs, but it has been believed that once T cells become too exhausted, this state becomes irreversible. The resu...
Altered signaling pathway activity in exhausted T cells was uncovered by the AUCell algorithm. xCELL, TIMER, QUANTISEQ, CIBERSORT and CIBERSORT-abs were performed to explore immune cell infiltration. Immune checkpoint inhibitor genes and TIDE methods were used to predict immunotherapy response. Finally,...
Cytotoxic T cell immunity in response to chronic infections and tumours is maintained by a specialized population of CD8T cells that exhibit hallmarks of both exhausted and memory cells and give rise to terminally differentiated exhausted effector cells that contribute to viral or tumour control. Impor...
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8+ T cells during HIV infection...
Cite:Weber E W, Parker K R, Sotillo E, et al. Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling[J]. Science, 2021, 372(6537): eaba1786. 或者Science, 372 (6537), eaba1786. • DOI: 10.1126/science.aba1786 ...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswere
T cells race to the scene in cancer and infection. To tease out what is special in cancer, scientists widen their scope and tool sets. This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, ...