functional and transcriptional differences between memory and exhausted antigen-specific CD8+T cells in human hepatitis C virus (HCV) infection before and after treatment. After viral cure, phenotypic changes in clonally stable exhausted T cell populations suggested differentiation toward a memory-like pro...
#技术#CD61 与 CD103 共定位,可抑制 TCR 信号耗竭进程,进而增强 CD8+T 细胞的抗肿瘤免疫作用 抗体名:见优宁维官网 浓度:见优宁维官网 % 靶点:见优宁维官网 宿主:见优宁维官网 用途:详见说明书 应用范围:见优宁维官网 纯度:见优宁维官网 % 产地:见优宁维官网 ...
single immune cell data sets were used to identify marker gene sets for exhausted CD8 + T cells (CD8Tex) in breast cancer. Machine learning methods were used
CD8+ T cell exhaustion is a state of dysfunction acquired in chronic viral infection and cancer, characterized by the formation of Slamf6+ progenitor exhausted and Tim-3+ terminally exhausted subpopulations through unknown mechanisms. Here we establish the phosphatase PTPN2 as a new regulator of the...
叶丽林团队及Rafi Ahmed,Di Yu等研究团队在2016年分别独立发现, 慢性病毒感染中,位于淋巴组织内的耗竭程度较低的CXCR5+TCF-1+ Tim3-CD8+T细胞作为耗竭前体细胞(progenitor exhausted T cell, Tpex),功能性响应PD-1 ICB。Tpex的发现打破了将耗竭T细胞作为“Zombie”细胞的固有印象,并立即成为T细胞耗竭领域的研究热点...
Persistent infections result in dysfunctional state of CD8 T cells associated with the expression of multiple inhibitory receptors. Recent studies have attempted to elucidate T cell subsets in chronic infections. Similarly, the chemokine receptor CX3CR1 has been recently three effector and memory subsets...
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differ...Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 ...Full operating ...
To assess the role of Egr2 in the CD8+ T cell exhaustion process, we utilised Egr2 floxed mice crossed to a Cd4-cre transgene to delete the Egr2 gene within all T cells31. Cd4-cre+ Egr2f/f mice (cKO), or Cd4-cre+ Egr2+/+ littermates (WT), were infected with LCMV-Cl13 and th...
Furthermore, CD39 enzymatic activity controlled GC-infiltrating CD39hiCD8+ T cell effector function, and blockade of CD39 efficiently enhanced their production of cytokines IFN-γ and TNF-α. Finally, high percentages of GC-infiltrating CD39hiCD8+ T cells correlated with tumor progression and ...
Publication Donor CD8+T Cells Prevent Toxoplasma gondii De-Encystation but Fail To Rescue the Exhausted Endogenous CD8+T Cell Population Rajarshi Bhadra, Dustin A. Cobb, Imtiaz A. Khan Infection and Immunity, July 2013, ASM Journals DOI:10.1128/iai.00784-12 ...