因此,CD8+T细胞生物学动态与HIV感染患者息息相关。在慢性感染和肿瘤中,持续的抗原刺激诱导耗竭性T细胞(exhausted T cell,Tx)的产生【2】。TX的典型特征是由TOX等转录因子驱动的转录组和表观组重塑介导的效应功能减弱和抑制性受体...
1#How to reinvigorate exhausted immune cells and stop cancer along the way 2#Reviving tired T cells to improve immuno-oncology treatments 3#Study identifies critical regulator of tumor-specific T cell differentiation 4#专家点评 | ...
共同通讯在Nature 在线发表题为“TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection”的研究论文,该研究发现耗尽的T细胞群的发展和维持需要胸腺细胞选择相关的高迁移率族蛋白盒(Tox)。
Cancer Cell. 2022 Oct 7:S1535-6108(22)00442-1. M28Z-BKO小鼠中:TILs和PB中都有更多的中央记忆T细胞; M28Z-BOE小鼠中:终分化效应T(Teff)细胞的比例增加。 这证明:BATF直接结合并调节效应基因和记忆相关基因的表达,降低效应T细胞比例,可使T细胞更多的向中央记忆T细胞分化,从而提高肿瘤杀伤能力。c-Junc-Jun...
1#How to reinvigorate exhausted immune cells and stop cancer along the way 2#Reviving tired T cells to improve immuno-oncology treatments 3#Study identifies critical regulator of tumor-specific T cell differentiation 4#专家点评 | 3篇Nature1篇Nat Immuno揭示调控耗竭CD8+T细胞的关键因子...
1#How to reinvigorate exhausted immune cells and stop cancer along the way 2#Reviving tired T cells to improve immuno-oncology treatments 3#Study identifies critical regulator of tumor-specific T cell differentiation 4#专家点评 | 3篇Nature1篇Nat Immuno揭示调控耗竭CD8+T细胞的关键因子...
该研究显示TOX在肿瘤和慢性病毒感染的exhausted T细胞中功能失调的TST中高度表达。 TOX表达由慢性TCR刺激和NFAT活化驱动。该研究假设TOX诱导的衰竭程序用于在诸如癌症的慢性抗原刺激的环境中防止T细胞过度刺激和活化诱导的细胞死亡。
疗，使得很多晚期癌症患者获得了长期缓解。然⽽，⽬前这类疗法仅对少数患者有效，⼤部 分患者要么不响应这类疗法，要么只有短期响应。论⽂⼀ 6⽉17⽇，发表在Nature杂志上题为“TOX is a critical regulator of tumour-specific T cell differentiation”的⼀篇论⽂[1]解释了为什么阻断肿瘤浸润T细胞上...
1016Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOXdoi:10.1136/jitc-2023-SITC2023.1016Background T cell exhaustion is one of the major barriers limiting efficacious anti-tumor therapy. Exhausted CD8 T cells (TEX) develop following persistent antigen stimulation and ...
The transcription factor TOX epigenetically reprograms CD8+ T cells to drive T cell exhaustion during chronic infection and cancer. Although they are necessary for T cell persistence, these changes contribute to diminished anti-tumor function in exhausted cells. This is a preview of subscription ...