We immunophenotyped CD8+ T cells for markers of terminal exhaustion, cytokine production, and lipid accumulation. Results Here we sought to define the role lipid metabolism plays in the progression of CD8+ T cell exhaustion. Inhibition of citrate transport from the mitochondria via SLC25A1 in CD8...
The expression of CD8Tex hub genes has been demonstrated to be critical markers for CD8 + T cells in breast cancer. While CD8 + T cells are critical for breast cancer development, we proposed that CLEC2D, CRTAM, and KLRB1 are associated with clinical characteristics. The comparison of...
2. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions that are met only after persistent exposure to antigen and inflammation. Here we show, however, that similar T cell populations exist in the early phase of acute infections1,...
Interleukin-4 (IL-4), a prototypical type 2 cytokine, has been reported to prolong the survival of T and B lymphocytes15,16. Here we proposed that IL-4 could rejuvenate the tumour-infiltrating exhausted T cells for enhanced cancer immunotherapy. We first produced a recombinant fusion protein ...
In the early stage, there is a subset of progenitor cells with stem cell-like characteristics (TCF-1+PD-1intTIM3low) that high expression of the transcription factor TCF-1 and increased surface markers such as Ly108, IL7R and CXCR5. Show abstract Immune aging – A mechanism in autoimmune...
<正>Defective cytokine production, expression of inhibitory receptors such as PD-1 and metabolic dysfunction are hallmarks of exhausted CD8 T cells that are exposed to high loads of antigen for prolonged periods in situations such as chronic infections or tumours. Recent research by us and others ...
Multiple markers of T cell exhaustion were identified on infiltrating LCH lesion T cells. While the significance of double-positive T cells in LCH is uncertain, similar cells have been reported in the target organs of several auto-immune conditions and hematological and solid malignancies, consistent...
(Supplementary Fig. 1b) or markers of cell proliferation, such as Ki-67 or 5-bromodeoxyuridine (BrdU) incorporation (Supplementary Fig. 1c,d). Following LCMV infection, there was a significant increase in the Ptpn2-deleted cells compared to control cells at 8 d and 15 d after infection, ...
The results demonstrated that TBAg stimulation could not induce an increased expression of IL-21 and Ki-67 in the CD4+CXCR5+ T cells of ATB patients, while the expression of these markers was significantly increased after PHA stimulation (Figure 3). These findings reveal that the function of ...
Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate TEX cells, but reinvigoration is not durable. A major unanswere