In chronic infections and cancers, T lymphocytes (T cells) are exposed to persistent antigen or inflammatory signals. The condition is often associated with a decline in T-cell function: a state called “exhaustion”. T cell exhaustion is a state of T cell dysfunction characterized by increased ...
Virax Biolabs, a biotechnology company specializing in diagnostic technology, is developing an advanced T-cell immunology platform to enable early diagnosis of post-viral syndromes like long COVID and conditions related to chronic inflammation and T-cell exhaustion. ...
In light of these promising results, we sought to determine if the vaccine could also stimulate the extant adaptive response in Toxo + humans, with the aim of preventing the T-cell exhaustion and therefore the parasite reactivation. Therefore, the NPL/T.gondii formulation’s ability to ...
CD4 + T cell exhaustionWuchereria bancrofti infectionlymphatic filariasisImmune ModulationLymphedemaWorldwide, more than 200 million people are infected with filariae which can cause severe symptoms leading to reduced quality of life and contribute to disability-adjusted life years (DALYs). In particular,...
Extrahepatic cholangiocarcinoma (ECCA) is a malignant tumor. The precise role of T-cell immunoreceptor with Ig and ITIM domains (TIGIT), an emerging immunosuppressive receptor, in ECCA, and its impact on CD8+ T cell exhaustion (Tex) remains unclear. W
Chimeric antigen receptor (CAR)-T cell adoptive immunotherapy is a promising cancer treatment that uses genetically engineered T cells to attack tumors. However, this therapy can have some adverse effects. CAR-T cell-derived exosomes are a potential alte
Increased interferon I signaling, DNA damage response and evidence of T-cell exhaustion in a patient with combined interferonopathy (Aicardi-Goutières Syndrome, AGS) and cohesinopathy (Cornelia de Lange Syndrome, CdLS) Sorina Boiu, Nikolaos Paschalidis, George Sentis, Theodora Manolakou, An...
Also, CAR-T cells have been engineered to prevent the expression of immune checkpoint molecules such as PD-1, which are often upregulated in the TME of GBM and contribute to T cell exhaustion. By knocking out these checkpoint molecules, CAR-T cells can resist the suppressive signals in the...
Moreover, Lck signaling has been shown to contribute to PD-1+ T cell exhaustion via CD28 co-stimulation in a humanized mouse model [82] (Fig. 3A and B). Fig. 3 Interaction of PD-1/PD-L1 between T cells and NSCLC cells. (A-B) The engagement of PD-1 in T cells and PD-1 ...
APRIL-based CAR T-cells.AAPRIL and BAFF bind to BAFF-R, TACI, and BCMA receptors which leads to the expression of PDL-1 on the cancer cell and induces T cell exhaustion usingof PD-1 on the T-cell surface.BAPRIL-base CARs can bind to the BCMA and TACI expressing multiple myeloma ...