T-cell exhaustionMolecular cytometrySingle-cell analysisMultiomicsA key step in the clinical production of CAR-T cells is the expansion of engineered T cells. To generate enough cells for a therapeutic product, cells must be cdoi:10.2139/ssrn.3488239Corselli, Mirko...
所谓T细胞耗竭(T Cell Exhaustion)就是指常见慢性感染和癌症患者体内T细胞功能丧失。由于长期暴露于持续性抗原或慢性炎症,疲惫的T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。不过这种耗竭是可以逆转的,至少部分逆转,主要是通过阻止PD-1之类的抑制性通路。 TEx Are a...
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性...
T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine pr
这篇综述聚焦 T 细胞衰老(senescence)与耗竭(exhaustion)。详细阐述其特征、机制及与疾病的关联,剖析二者区别与联系。对理解免疫系统功能、疾病发病机制意义重大,为精准免疫调节策略提供理论依据。 引言 T 细胞作为适应性免疫的关键效应细胞,通过细胞毒性介导的病原体清除(借助穿孔素和颗粒酶)以及细胞因子驱动的免疫调节...
T-cell exhaustion is a broad term used to describe T cell dysfunction resulting from chronic stimulation. Exhausted T cells present with a distinct phenotype including overexpression of inhibitory markers such as PD-1, LAG-3 and TIM-3 as well as impairment in their ability to release pro-inflam...
A Human In Vitro T Cell Exhaustion Model for Assessing Immuno-Oncology Therapies. (Springer, 2020). 】 (3)补充信息T细胞治疗 : 用5 µg/mL 放线菌素D(Merck;目录号 A9415)处理naive CD4+ T细胞16h,如2述。 使用下列免疫抑制药物进行TCR信号通路抑制: Rapamycin雷帕霉素(100 nM;Merck; cat. num...
suggests that T cell exhaustion is partly driven by a shift in nutrient metabolism. T cell exhaustion is accompanied by altered histone acetylation, which in turn relies on the availability of acetyl-CoA. In mammalian cells, acetyl-CoA is metabolized from acetate by the enzyme ACSS2, or from ...
Next, we determined whether the high tumor cholesterol content induces T cell exhaustion by upregulating immune checkpoint expression in tumor-infiltrating T cells. Similar to tumor-infiltrating T cells, CD8+ T cells cultured in vitro under standard conditions can also be separated into PD-1low2B4...
Budimir N, Thomas GD, Dolina JS, Salek-Ardakani S.Reversing T-cell Exhaustion in Cancer: Lessons Learned from PD-1/PD-L1 Immune Checkpoint Blockade. Cancer Immunol Res. 2022 Feb;10(2):146-153. McLane LM, Abdel-Hakeem MS, Wherry EJ.CD8 T Cell Exhaustion During Chronic Viral Infection an...