近日，来自美国宾夕法尼亚大学的E. John Wherry带领团队在Science Immunology杂志以 In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40 发表了他们最新的研究成果，他们建立一种体外T细胞模型，能够很好的模拟慢性感染或者癌症引起的T细胞耗竭生物学功能，他们将这种...
DNA结合蛋白2抑制剂(Id2)已被证明在T细胞发育和CD8+T细胞免疫中发挥重要作用。然而,Id2在CD8+T细胞衰竭中的作用尚不清楚。 2024年1月29日,上海大学陈亮、空军军医大学朱平及蒋建利共同通讯在Cellular & Molecular Immunology(IF 24)在线发表题...
上海大学陈亮、空军军医大学朱平及蒋建利共同通讯在Cellular & Molecular Immunology(IF 24)在线发表题为“Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex”的研究论文,该研究发现Id2通过转录和表观遗传调控Texprog细胞的产生及其向Texterm细胞的转化。Id2基...
In contrast, the proliferation of the CD4+ T cells appears to be limited only by the exhaustion of the culture medium. The results also show that the proliferative responses of both CD4+ and CD8+ T cells are inhibited in homologous serum but that it is the CD8+ subset that is more ...
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性...
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性受体(IRS)表达增高和持续,表观和转录谱改变,代谢方式不同,不能...
(DCs) can also carry tumor antigenic peptides from the tumor to dLN [23]. During the late stages of cancer, CD8+ T cells in lymphoid organs of tumor-bearing mice and patients lose their effector function, ultimately diminishing the antitumor response [24]. 外周免疫系统与肿瘤微环境(TME)之间...
2023年8月10日,山东大学齐鲁医院孔北华教授团队在Cell Reports上发表题为“Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-b axis”的文章。 文章证明了转录因子19(TCF19)是癌症基因组图谱(TCGA)-EC队列中MSI和微卫星稳定(MSS)患...
Tumor-infiltrating T cells are known to encounter chronic antigens and hypoxia, which results in exhaustion and dysfunction. New data show that lactate fermentation, a characteristic of solid tumors, promotes the uptake of lactate into T cells via the monocarboxylate transporter MCT11, which reduces...
Anne M van der Leun et al, CD8+ T cell states in human cancer: insights from single-cell analysis, Nat Rev Cancer. 2020 Apr;20(4):218-232. doi: 10.1038/s41568-019-0235-4. Satomi Ando, and Koichi Araki.CD8 T-cell heterogeneity during T-cell exhaustion and PD-1-targeted immunotherapy...