Katharina EmmerigJulia S. NeitzBarbara BeckRika DraenertWolfgang HiddemannMarion SubkleweBloodLichtenegger FS, Schnorfeil FM, Emmerig K, Neitz JS, Beck B, Draenert R, et al. Pseudo-exhaustion of CD8+ T cells in AML. Blood (2013) 122:2615....
an ongoing pandemic disease. In patients with COVID-19, CD8+T cells exhibiting activated phenotypes are commonly observed, although the absolute number of CD8+T cells is decreased. In addition, several
The CD155/TIGIT axis has attracted considerable interest as an emerging immune checkpoint with potential applications in cancer immunotherapy. Our research focused on investigating the role of CD155/TIGIT checkpoints in the progression of triple-negative
Liver transplantation (LT) rejection remains the most pervasive problem associated with this procedure, while the mechanism involved is still complicated and undefined. One promising solution may involve the use of myeloid-derived suppressor cells (MDSC)
Dysfunctional T Cells Tumor Infiltrating Lymphocytes (TILs) are immune cells that exist in the tumor. In concept, these immune cells, particularly CD8+, work to detect the tumor and (most importantly for human health) destroy the tumor. As such, the presence of TILs have been studied as a ...
During the late stages of cancer, CD8+ T cells in lymphoid organs of tumor-bearing mice and patients lose their effector function, ultimately diminishing the antitumor response [24]. 外周免疫系统与肿瘤微环境(TME)之间的相互作用对于效应性CD8+ T细胞的抗肿瘤反应至关重要。因此,从治疗角度来看,正确...
CD8T cells are important in protective immunity against intracellular pathogens and tumors. In chronic infections or cancer, CD8T cells are constantly exposed to antigens and inflammatory signals. Such excessive and constitutive signals lead to the deterioration of T cell function, called 'exhaustion'...
However, functional CD8+ T-cells capable of recognizing tumors constitute only 10 % of intratumoral CD8+ T-cells [19]. TNBC exhibits a moderately to highly heterogeneous immune microenvironment regulated by various factors. Effective anti-tumor immune responses rely on activated CD8+ T-cells ...
Exhausted CD8+ T cells expressed up to seven inhibitory receptors. Coexpression of multiple distinct inhibitory receptors was associated with greater T cell exhaustion and more severe infection. Regulation of T cell exhaustion by various inhibitory pathways was nonredundant, as blockade of the T cell...
Zhang, N. & Bevan, M. J. CD8+T cells: foot soldiers of the immune system.Immunity35, 161–168 (2011). ArticleCASPubMedPubMed CentralGoogle Scholar Chang, J. T., Wherry, E. J. & Goldrath, A. W. Molecular regulation of effector and memory T cell differentiation.Nat. Immunol.15, ...