an ongoing pandemic disease. In patients with COVID-19, CD8+T cells exhibiting activated phenotypes are commonly observed, although the absolute number of CD8+T cells is decreased. In addition, several
of CD8^(+)T cells is decreased.In addition,several studies have reported an upregulation of inhibitory immune checkpoint receptors,such as PD-1,and the expression of exhaustion-associated gene signatures in CD8^(+)T cells from patients with COVID-19.However,whether CD8^(+)T cells are truly...
T cell exhaustion is an induced state of dysfunction that arises in response to chronic infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not known whether that chromatin landscape is fixed or plastic following t
Sustained overexpression of the inhibitory molecule PD-1 is observed in exhausted CAR T cells [30], similar to that observed in CD8 T cells exhausted following chronic viral infection [61]. The inhibitory signal from PD-1 is considered to contribute to exhaustion, since PD-1/PD-L1 blockade ...
Immunosenescence of CD8+T cells was suggested to contribute to APDS pathogenesis. However, the constitutive activation of T cells in APDS may also result in T cell exhaustion. Therefore, we studied exhaustion of the CD8+T cell compartment in APDS patients and compared them with healthy controls ...
Expression of PD-1, Tim-3, Lag-3 and CD38 on CD8 T cells from the closest pre-therapy time-point to seroconversion was measured by flow cytometry, and correlated with surrogate markers of HIV-1 disease (HIV-1 plasma viral load (pVL) and CD4 T cell count) and the trial endpoint (...
The CD155/TIGIT axis has attracted considerable interest as an emerging immune checkpoint with potential applications in cancer immunotherapy. Our research focused on investigating the role of CD155/TIGIT checkpoints in the progression of triple-negative
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Results Depletion of CD4 T cells promotes the exhaustion of CD8 T cells with a concomitant increase in IL-17-producing CD8 T (Tc17) cells in the tumor. Unlike IFN-γ-producing CD8 T (Tc1) cells, tumor-infiltrating Tc17 cells exhibit CD103KLRG1IL-7Rαhi tissue resident memory-like ...
the tumor to dLN [23]. During the late stages of cancer, CD8+ T cells in lymphoid organs of tumor-bearing mice and patients lose their effector function, ultimately diminishing the antitumor response [24]. 外周免疫系统与肿瘤微环境(TME)之间的相互作用对于效应性CD8+ T细胞的抗肿瘤反应至关重要。