T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among exhausted CD8+ tumor-infiltrating lymphocytes, the terminally exhausted subset contributes directly to tumor cell killing owing to its cytotoxic effector function. However
To analyze the transcriptional-metabolic programs along the developmental trajectories of exhausted T cells, we performed single-cell (sc) RNA sequencing of CD44+PD-1hiCD8+T cells isolated from chronically infected wild-type (WT) mice after infection with the clone 13 strain of lymphocytic choriomen...
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015, 11, e1005177. [CrossRef]Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, et al. CD39 expression identifies terminally exhausted CD8+ T cells. PLoS Pathog. 2015; 11(10):e1005177....
Intratumoral and intrahepatic HBV-specific T cells were enriched for two Trm cell subsets that were PD-1loTOXlo, despite being clonally expanded. High frequencies of intratumoral terminally exhausted T cells were uncommon. Patients with tumor-infiltrating HBV-specific CD8+ Trm cells exhibited longer-...
Terminally exhausted CD8 +T cells contribute to age-dependent severity of human metapneumovirusdoi:10.4049/jimmunol.210.Supp.59.42ObjectiveHuman metapneumovirus (HMPV) is a leading cause of acute respiratory infection with severe morbidity and mortality among older adults. HMPV seropositivity is ...
Terminally exhausted CD8+ T cells marked by high levels of CD39 are most impaired in their effector function.Prakash, K. GuptaJernej, GodecDavid, WolskiEmily, AdlandKathleen, YatesKristen, E. PaukenCormac, CosgroveCarola, LedderoseWolfgang, G. Junger...
Background Tumor-infiltrated CD8+T cell (TIL) heterogeneity is serving as one of the major hurdles in successful PD1 therapy. According to recent reports, among two subpopulations of exhausted CD8+TILs, (progenitor-exhausted, CD8+TPEX; terminally-exhausted, CD8+TTEX), CD8+TTEX do not respond ...
Results: The percentages of CD8 T cells expressing PD-1, TIM-3, Ki-67, TOX, and CD101 in TAL were higher than those in PBMCs and similar to those in TILs. When we compared frequencies of terminally exhausted CXCR5-CD101 PD-1 CD8 T cells (Ttex) among PBMCs, ...
Herein, we examined distinct exhaustion status of CD8(+) TILs based on the level of programmed cell death-1 (PD-1) and thymocyte selection-associated high mobility group box protein (TOX) expression in urothelial bladder cancer. We also evaluated the reinvigoration of exhausted CD8(+) TILs ...
CD39 identifies terminally exhausted CD8+ T cells in mice with chronic LCMV infection.Prakash, K. GuptaJernej, GodecDavid, WolskiEmily, AdlandKathleen, YatesKristen, E. PaukenCormac, CosgroveCarola, LedderoseWolfgang, G. JungerSimon, C. Robson...