T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among exhausted CD8+ tumor-infiltrating lymphocytes, the terminally exhausted subset contributes directly to tumor cell killing owing to its cytotoxic effector function. However
Terminally exhausted CD8+ T cells marked by high levels of CD39 are most impaired in their effector function.Prakash, K. GuptaJernej, GodecDavid, WolskiEmily, AdlandKathleen, YatesKristen, E. PaukenCormac, CosgroveCarola, LedderoseWolfgang, G. Junger...
Herein, we show that the ectonucleotidse CD39 is a marker of exhausted CD8+ T cells. CD8+ T cells specific for HCV or HIV express high levels of CD39, but those specific for EBV and CMV do not. CD39 expressed by CD8+ T cells in chronic infection is enzymatically active, co-...
To analyze the transcriptional-metabolic programs along the developmental trajectories of exhausted T cells, we performed single-cell (sc) RNA sequencing of CD44+PD-1hiCD8+T cells isolated from chronically infected wild-type (WT) mice after infection with the clone 13 strain of lymphocytic choriomen...
exhausted/senescent (CD27-CD28- and/or CD57+) terminally differentiated CD8+ cells in the blood and with increased tumor infiltration by FOXP3+ cells. ... L Berben,G Floris,C Kenis,... - 《Clinical & Translational Immunology》 被引量: 0发表: 2020年 Cytometric Deep Proling of the CD8...
Intratumoral and intrahepatic HBV-specific T cells were enriched for two Trm cell subsets that were PD-1loTOXlo, despite being clonally expanded. High frequencies of intratumoral terminally exhausted T cells were uncommon. Patients with tumor-infiltrating HBV-specific CD8+ Trm cells exhibited longer-...
Results: The percentages of CD8 T cells expressing PD-1, TIM-3, Ki-67, TOX, and CD101 in TAL were higher than those in PBMCs and similar to those in TILs. When we compared frequencies of terminally exhausted CXCR5-CD101 PD-1 CD8 T cells (Ttex) among PBMCs,...
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015, 11, e1005177. [CrossRef]Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, et al. CD39 expression identifies terminally exhausted CD8+ T cells. PLoS Pathog. 2015; 11(10):e1005177....
CD39 identifies terminally exhausted CD8+ T cells in mice with chronic LCMV infection.Prakash, K. GuptaJernej, GodecDavid, WolskiEmily, AdlandKathleen, YatesKristen, E. PaukenCormac, CosgroveCarola, LedderoseWolfgang, G. JungerSimon, C. Robson...
Herein, we examined distinct exhaustion status of CD8(+) TILs based on the level of programmed cell death-1 (PD-1) and thymocyte selection-associated high mobility group box protein (TOX) expression in urothelial bladder cancer. We also evaluated the reinvigoration of exhausted CD8(+) TILs ...