Terminally exhausted CD8+ T cells marked by high levels of CD39 are most impaired in their effector function.Prakash, K. GuptaJernej, GodecDavid, WolskiEmily, AdlandKathleen, YatesKristen, E. PaukenCormac, CosgroveCarola, LedderoseWolfgang, G. Junger...
2 Tumor infiltrating PD-1+TIM-3+CD8+ T cells are PD-1+TCF-1–TIM-3+ terminally exhausted CD8+ T cells, which respond to IL-10–Fc through IL-10 receptor. a-d, The experimental setting was the same as described in Fig. 1. a-c, Data are representative of two independent ...
In the mouse model of chronic viral infection, CD39 demarcates a subpopulation of dysfunctional, exhausted CD8+T cells with the phenotype of irreversible exhaustion. CD39 expression therefore identifies terminal CD8+T cell exhaustion in mice and humans, and implicates the purinergic pathway in the ...
Exhausted T cells in the tumor microenvironment are major targets of immunotherapies. However, the exhaustion status of CD8+ tumor-infiltrating lymphocytes (TILs) in bladder cancer has not been comprehensively evaluated. Herein, we examined distinct exhaustion status of CD8+ TILs based on the level ...
Terminal T cell exhaustion is characterized by metabolic reprogramming To analyze the transcriptional-metabolic programs along the developmental trajectories of exhausted T cells, we performed single-cell (sc) RNA sequencing of CD44+PD-1hiCD8+T cells isolated from chronically infected wild-type (WT) ...
exhausted/senescent (CD27-CD28- and/or CD57+) terminally differentiated CD8+ cells in the blood and with increased tumor infiltration by FOXP3+ cells. ... L Berben,G Floris,C Kenis,... - 《Clinical & Translational Immunology》 被引量: 0发表: 2020年 Cytometric Deep Proling of the CD8...
Intratumoral and intrahepatic HBV-specific T cells were enriched for two Trm cell subsets that were PD-1loTOXlo, despite being clonally expanded. High frequencies of intratumoral terminally exhausted T cells were uncommon. Patients with tumor-infiltrating HBV-specific CD8+ Trm cells exhibited longer-...
Results: The percentages of CD8 T cells expressing PD-1, TIM-3, Ki-67, TOX, and CD101 in TAL were higher than those in PBMCs and similar to those in TILs. When we compared frequencies of terminally exhausted CXCR5-CD101 PD-1 CD8 T cells (Ttex) among PBMCs,...
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. PLoS Pathog. 2015, 11, e1005177. [CrossRef]Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, et al. CD39 expression identifies terminally exhausted CD8+ T cells. PLoS Pathog. 2015; 11(10):e1005177....
Herein, we show that the ectonucleotidse CD39 is a marker of exhausted CD8+ T cells. CD8+ T cells specific for HCV or HIV express high levels of CD39, but those specific for EBV and CMV do not. CD39 expressed by CD8+ T cells in chronic infection is enzymatically active, co-...