所谓T细胞耗竭(T Cell Exhaustion)就是指常见慢性感染和癌症患者体内T细胞功能丧失。由于长期暴露于持续性抗原或慢性炎症,疲惫的T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。不过这种耗竭是可以逆转的,至少部分逆转,主要是通过阻止PD-1之类的抑制性通路。 TEx Are a...
与急性感染和疫苗接种后,效应T细胞(Teff)和记忆T细胞(Tmem)细胞的发育不同,在抗原持续刺激的慢性感染和癌症期间,T细胞记忆不能有效地发展,T细胞变得精疲力竭,称之为T细胞耗竭(Tex)。Tex细胞在功能上有别于Teff和Tmem细胞,其特点是效应功能丧失,抑制性...
然而，在慢性感染和肿瘤中，T细胞长期暴露于抗原以及炎症之下，其逐渐进入一种功能失常的状态，被称为T细胞耗竭（T cell exhaustion）【1】。其主要表现为杀伤功能的丧失，多种抑制性受体的上调（包括 PD-1, Tim3, CTLA-4等等），以及增值分化能力的减退【1】。因此，预防T细胞耗竭或者逆转耗竭的T细胞，恢复T 细胞...
Additionally, elevated collagen correlates with decreased total CD8T cells and increased exhausted CD8T cell subpopulations in murine and human lung tumors. Collagen-induced T cell exhaustion occurs through the receptor LAIR1, which is upregulated following CD18 interaction with collagen, and induces T...
T Cell Exhaustion | Cell and Cytokine Profiling T-cell exhaustion is a broad term used to describe T cell dysfunction resulting from chronic stimulation. Exhausted T cells present with a distinct phenotype including overexpression of inhibitory markers such as PD-1, LAG-3 and TIM-3 as well as...
Progressive development of T cell exhaustion. Exhausted耗竭T细胞是T细胞分化的独特细胞系,来源于CD127+记忆前体细胞,在表型和机制上与其他T细胞功能障碍(如无能anergy和衰老senescence)不同。 感染后,幼稚T细胞被抗原、共刺激(co-stimulation)和炎症激活,它们呈指数级增殖,形成效应群体。
T cell exhaustion. Nat Immunol 12:492- 499.Wherry E J.T cell exhaustion.Nature Immunology. 2011Wherry EJ. 2011. T cell exhaustion. Nat. Immunol. 131:492- 499.Wherry EJ. 2011. T cell exhaustion. Nat. Immunol. 12:492- 499. http:// dx.doi.org/10.1038/ni.2035....
所谓T细胞耗竭(T Cell Exhaustion),指的是常见于慢性感染和癌症患者体内T细胞功能丧失的一种现象 由于长期暴露于持续性抗原和炎症,精疲力竭的T细胞逐渐失去效应功能,这种耗竭是可逆转的 当遭受慢性感染时...
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents...
Recent data from models of viral infection show that the precursors of terminally exhausted T cells emerge early during disease course, prior to continuous signalling through the T cell receptor. I speculate that these findings might indicate that, at least in some settings, T cell exhaustion may...