T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure...
Gene signatures of regulatory T cells, Th1 cells, Th2 cells, Th17 cells, T follicular helper cells, CD4 tissue-resident memory T cells, and CD8 tissue-resident memory T cells were enriched in TCMR biopsies compared with NR biopsies. T-cell exhaustion and anergy were also molecular attributes...
CD8+ T cells responding to chronic infections or tumors acquire an ‘exhausted’ state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T cell
LINE1以非经典转录本变体形式剪切来调控T细胞静止和耗竭状态《Nature Genetics》意大利米兰大学,IF: 41.307,中科院一区 Cite:Marasca, F., Sinha, S., Vadalà, R. et al.LINE1 are spliced in non-canonical t…
However, the studies have revealed that there occurs a dysfunction and exhaustion of T cells in cancer patients and this dysfunctioning is one of the important features of many cancers (Jiang et al., 2015). The T cell function gets impaired because of the presence of various immunosuppressive ...
Molecular and cellular insights into T cell exhaustion. Nat. Rev. Immunol. 15, 486–499 (2015). CAS PubMed PubMed Central Google Scholar Huang, Q. et al. The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining ...
Enrichment scores of T cell exhaustion gene set (TOX, LAG3, PDCD1, HAVCR2, ITGAE, TIGIT, CXCL13) and T cell stemness gene set (TCF7, CDCR5, CD28, GZMK, CCR7, IL7R, BCL6, SELL, CD27) were calculated using AUCell algorithm implemented in SCENIC(Aibar et al., 2017). Cell ...
Single-cell transcriptomic reveals heterogeneous malignant B cell phenotypes in PCNSL.AUMAP plot of 73,896 total single-cell transcriptomes aggregated from five samples (patient 1: biopsy, blood, CSF; patient2: biopsy, blood).BGene and protein (C) cell markers of the clusters identified by singl...
CD8+ T cell exhaustion is a state of dysfunction acquired in chronic viral infection and cancer, characterized by the formation of Slamf6+ progenitor exhausted and Tim-3+ terminally exhausted subpopulations through unknown mechanisms. Here we establi
The immune checkpoint B7x expands tumor-infiltrating Tregs and promotes resistance to anti-CTLA-4 therapy Article Open access 06 May 2022 The cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis Article Open access 15 May 2024 Data...