2023年9月23日,Nature杂志发表了美国学者一篇题为“The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion”的文章【1】,首次揭示了杀伤性 T 细胞耗竭与人体交感神经(“战斗或逃跑”)应激反应之间的关系;研究进一...
然而，在慢性感染和肿瘤中，T细胞长期暴露于抗原以及炎症之下，其逐渐进入一种功能失常的状态，被称为T细胞耗竭（T cell exhaustion）【1】。其主要表现为杀伤功能的丧失，多种抑制性受体的上调（包括 PD-1, Tim3, CTLA-4等等），以及增值分化能力的减退【1】。因此，预防T细胞耗竭或者逆转耗竭的T细胞，恢复T 细胞...
近日,德国莱布尼茨免疫治疗研究所Luca Gattinoni实验室和哈佛医学院Shiladitya Sengupta实验室等合作在Cell杂志发表了题为Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy的研究文章,作者...
Enhanced mannose metabolism attenuates differentiation to T cell exhaustion and improves anti-tumor function in vivo 增强的甘露糖代谢减轻了向T细胞衰竭的分化,并在体内改善了抗肿瘤功能。 Para_01 由于减少的甘露糖代谢导致了T细胞功能障碍,我们假设恢复甘露糖代谢可以增强T细胞的抗肿瘤功能。
在肿瘤抑制性微环境中,肿瘤抗原特异性T细胞发生功能性耗竭(T cell exhaustion),是导致机体不能有效清除肿瘤细胞的重要原因之一。相较于急性感染或者疫苗免疫情形下诱导形成的记忆性T细胞(Memory T cell, TMEM),耗竭性T细胞(Exhausted T cell, TEX)渐进式失去效应功能、增殖能力及记忆潜力,并持续性高表达包括PD-1在内...
癌症免疫监测(Cancer immunosurveillance)主要依赖传统 CD8 T 细胞识别肿瘤新抗原(Neoantigen)进而杀伤癌细胞。然而癌细胞能通过上调具有免疫抑制功能的 PD-L1 与传统 CD8 T 细胞中的 PD-1 受体相互作用,使 T 细胞的效用功能减少,甚至丧失,从而诱导T 细胞耗竭(T cell exhaustion)。
The enrichment of exhausted CD8+ T cell (CD8+ Tex) in the tumor microenvironment is one of the important reasons leading to the poor efficacy of immunotherapy. Recent studies have reported many reasons leading to the CD8+ T cell exhaustion. In addition to cancer cells, myeloid cells can also...
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T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine pr
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells. Exhaustion prevents...