1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 2021; 12: 715234.
1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 2021; 12: 715234. 会议内容 时间:2021年10月22-23日 地点:上海(酒店后期定向通知) 规模:600-800人 主办单位:生物制品圈、抗体圈 协办单位:百英生物 学术支持:百奥泰生物 赞助单位:丹纳赫生命科学、香港奥星集团、...
Figure 1. CD8 T cell exhaustion correlates with macrophage abundance in the TME Figure S1. Onset of CD8 T cell exhaustion is antigen-specific and correlates with macrophage abundance in multiple mouse cancer models 2. CD8 Tex在TME中长期驻留后表达单核/巨噬细胞相关因子 TAM丰度与CD8 T细胞耗竭之间...
2.Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006 Feb 9;439(7077):682-7. doi: 10.1038/nature04444. Epub 2005 Dec 28.3.CD8+ T Cell Exhaustion in Cancer....
1.CD8+ T Cell Exhaustion in Cancer. FrontImmunol. 2021; 12: 715234. 2.Improving CAR T-Cell Persistence. Int J MolSci. 2021 Oct; 22(19): 10828. 3. Knowns and Unknowns about CAR-T Cell Dysfunction.Cancers (Basel). 2022 Feb; 14(4): 1078....
‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses. Nat. Immunol. 23, 836–847 (2022). Article CAS PubMed Google Scholar McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T cell exhaustion during chronic viral infection and cancer. Annu. ...
1 Hashimoto, M. et al. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions. Annual review of medicine 69, 301-318, doi:10.1146/annurev-med-012017-043208 (2018).2 McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. CD8 T Cell Exhaustion During ...
Nutrient-driven histone code determines exhausted CD8+T cell fates 背景:持续的抗原刺激,如癌症和慢性感染,会导致T细胞耗竭(T cell exhaustion, TEX)--一种效应功能受损的状态。与功能性效应T细胞(effectior T cells, TEFF)相比,TEX细胞的特点是高表达抑制性受体,如程序性死亡受体1(programmed Death-1, PD-1)...
近日,来自Vanderbilt-Ingram癌症中心的Mary Philip和纪念斯隆-凯特琳癌症中心的Andrea Schietinger合作在Nature Reviews Immunology上发表题为CD8+ T cell differentiation and dysfunction in cancer的综述。本综述总结回顾了CD8+T细胞在肿瘤中的分化与功能障碍。
1 Hashimoto, M. et al. CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.Annual review of medicine69, 301-318, doi:10.1146/annurev-med-012017-043208 (2018). 2 McLane, L. M., Abdel-Hakeem, M....