基础E3连接酶依赖的生物调控过程—包含真菌的代谢途径，植物的植物激素信号通路以及人类对不同细胞因子、氧化还原压力、DNA损伤试剂以及降解类药物的多种响应等—均依赖于CAND1。SCFs是CRL（cullin-RING ligase）E3酶超家族的成员之一。它由两组已预装配完成的亚复合物构成，CUL1-RBX1复合物可以启动招募至SKP1-Fbp亚基...
基础E3连接酶依赖的生物调控过程—包含真菌的代谢途径,植物的植物激素信号通路以及人类对不同细胞因子、氧化还原压力、DNA损伤试剂以及降解类药物的多种响应等—均依赖于CAND1。 SCFs是CRL(cullin-RING ligase)E3酶超家族的成员之一。它由两组已预装配完成的亚...
structure of the SCF E3 ligase complexregulation of SCF activitycullinヽontaining ubiquitin E3 ligaseMany non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT...
The process of covalently attaching ubiquitin to another protein. Ubiquitylation is accomplished via an enzymatic cascade of an E1 ubiquitin activating enzyme, an E2 ubiquitin conjugating enzyme, and an E3 ubiquitin ligase. Proteasome A large protein complex that catalyses the proteolytic destruction of...
The SCF ubiquitin E3 ligase regulates ubiquitin-dependent proteolysis of many regulatory proteins such as p27Kip1, IκB, and β-catenin. We report the isolation of a CUL1 binding protein, p120CAND1. We found the majority of CUL1 is in a complex with CAND1 and ROC1 independent of SKP1 ...
英文名称:Recombinant Talaromyces stipitatus E3 ubiquitin ligase complex SCF subunit sconC sconCRecombinant Talaromyces stipitatus E3 ubiquitin ligase complex SCF subunit sconC sconC is available 2 ,中文名称:重组Stiptatus Talaromyces E3泛素连
scf-complex 例句 释义: 全部 更多例句筛选 1. SCF complex is a very important ubiquitin E3 ligase which has been exploited very well in plants. SCF复合体是一种非常重要的E3泛素连接酶,在植物中研究的最为深入。 www.chinagene.cn© 2025 Microsoft 隐私声明和 Cookie 法律声明 广告 帮助 反馈...
The F-box protein is the substrate recognition subunit of SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase complex, a multicomponent RING-type E3 ligase involved in the regulation of numerous cellular processes by targeting critical regulatory proteins for ubiquitination. However, whether and how F-box ...
Abstract The abundance of the cyclin-dependent kinase (CDK) inhibitor p57Kip2, an important regulator of cell cycle progression, is thought to be controlled by the ubiquitin-proteasome pathway. The Skp1/Cul1/F-box (SCF)-type E3 ubiquitin ligase complex SCFSkp2 has now been shown to be respo...
The invention provides ubiquitin variants that specifically bind to SCF E3 ligases, and use of these variants to modulate the activity of SCF E3 ligases.