CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activationEnzymesPost-translational modificationsAn emerging mechanism of ubiquitylation involves partnering of two distinct E3 ligases. In the best-characterized E3-E3 pathways, ARIH-family RING-between-RING (RBR) E3s ligate ...
近日,北京大学基础医学院系统生物医学研究所尹玉新教授团队在The EMBO Journal上发表了题为“Structural Insights into the Ubiquitylation Strategy of the Oligomeric CRL2FEM1B E3 Ubiquitin Ligase”的文章,报道了多聚形态E3泛素连接酶CRL2FEM1B在NEDD8修饰激活前,NEDD8修饰激活后与小分子量底物BEX2(约15kDa)结合...
2024年2月28日,复旦大学张英梅、葛均波及中国科学院分子细胞科学卓越创新中心胡荣贵共同通讯在Cell Discovery(IF=34)在线发表题为“The E3 ubiquitin ligase MARCH2 protects against myocardial ischemia-reperfusion injury through inhibiting pyro...
a, Structure representing TS2: ubiquitin transfer from ARIH1 to SCF substrate. The Ub-guided helix of ARIH1 and ensuing Rcat domain bound to ubiquitin form a ubiquitin transferase module barricaded by the switch helix of ARIH1.b, Approximately 100° reorientation of ubiquitin transferase module (...
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science 286, 1321–1326 (1999). CAS PubMed Google Scholar Verdecia, M. A. et al. Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol. Cell 11...
E3 ubiquitin ligases often reside in multiple subcellular compartments in neurons, and thus defining the precise compartment relevant for a specific biological function may not be trivial. Targeting an E3 ligase to a specific subcellular locale in structure–function analyses using specific peptide motifs...
样本:CLIA Kit for Human E3 ubiquitin-protein ligase AMFR 检测方法:夹心法 应用:夹心法 检测限:血清、血浆、组织匀浆、细胞培养物上清或其它相关液体 货号:FS-C6349 是否进口:是 标本要求: 1.血清: 室温血液自然凝固10-20分钟后,离心20分钟左右(2000-3000转/分)。仔细收集上清。保存过程中如有沉淀形成,应再...
Cellular biology Characterization of a novel E3 ubiquitin ligase in Fanconi anemia HARVARD UNIVERSITY Alan David D'Andrea GurtanAllan MitchellFanconi anemia (FA) is a rare recessive disorder characterized clinically by congenital defects, bone marrow failure, and cancer predisposition. Abnormalities can ...
Structure and Biochemistry of the Polycomb Repressive Complex 1 Ubiquitin Ligase Module Polycomb Group Proteins Book2017, Polycomb Group Proteins A.G. Cochran Explore book Abstract Polycomb repressive complex 1 (PRC1) is the E3 ubiquitin ligase responsible for the majority of ubiquitin incorporation at...
Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein substrates to be degraded by the ubiquitin-proteasome system. Mutations leading to deregulation of degron functionality disrupt control of protein abundance due to mistargeting of proteins destined for degradation and often...