2022年6月29日,来自哈佛大学的Tom A. Rapoport和Peiqiang Feng共同通讯,在Nature在线发表了题为A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel的科研论文,文章中作者发现E3连接酶复合物中央存在孔道结构,Pex5经由该孔道由过...
参考文献(可上下滑动): (1) Lisztwan, J.; Imbert, G.; Wirbelauer, C.; Gstaiger, M.; Krek, W.The von Hippel−Lindau Tumor Suppressor Protein Is a Component of an E3 Ubiquitin Protein Ligase Activity. Genes Dev. 1999, 13 (14),1822−1833 (2) Soares, P.; Gadd, M. S.; Frost...
Key words: plant pathology; RING; E3 ubiquitin ligase; stress resistance; disease resistance 0 引言泛素是一个由 76 个氨基酸残基组成的高度保守的多肽,广泛分布于各类细胞,被泛素标记的蛋白质将被特异性识别,其中多聚泛素化的蛋白将被特异性降解从而调控细胞周期,信号传导,DNA 修复,细胞凋亡等过程。而单泛素...
terminal of TOX4 through its coiled-coil and SPRY structural domains. Immunofluorescence confocal microscopy showed that they can co-localize both in the cytoplasm and nucleus. Furthermore, TRIM65 mediated the K48 ubiquitination and degradation of TOX4 depending on its E3 ubiquitin ligase activity. ...
Lu J, Qian Y, Altieri M, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently ...
(2010). The E3 ubiquitin ligase activity of an insect anti-apoptotic gene (SfIAP) is required for plant stress tolerance. Physiological and Molecular Plant Pathology 74: 351-362Kabbage, M. et al. The E3 ubiquitin ligase activity of an insect anti-apoptotic gene (SfIAP) is required for ...
Arabidopsis LNPs have E3 ubiquitin ligase activity and that LNP1 can directly ubiquitinates RHD3. Our data show that after ER fusion is completed, RHD3 isdegradedby LNPs so thatnascent3-wayjunctionscan bestabilizedand atubularER network can be maintained....
近日,中科院上海有机化学研究所生命有机化学国家重点实验室的潘李锋课题组在Science Advances发表了题为Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain-binding...
在该过程中,起决定性作用的E3泛素化连接酶能介导泛素蛋白连接到靶蛋白上,因此针对E3进行PROTAC药物的弹头及分子胶降解剂(Molecular glue degrader, MGD)正逐渐被人们所关注和深入探究。最近,来自阿斯利康的两位研究者联合在JMC上发表综述文章,总结近年来基于结构的先导化合物发现策略(Fragment-based lead discovery, FB...
Given the strong correlation of Rhbdf2 activity with Trim31 E3 ubiquitin ligase activity, to thoroughly explore whether the Trim31–Rhbdf2 interaction significantly and positively contributes to the protective function of Trim31 on hepatic steatosis, a lentivirus loaded Trim31 with a RING-finger doma...