By better understanding the mechanisms by which E3 ubiquitin ligases regulate biological processes and their exact role in carcinogenesis, we can improve the development of specific E3 ubiquitinligase inhibitors and pave the way for novel treatment strategies for cancer patients.Barbara C Snoek[1][1]...
E3 ubiquitin ligases are the key enzymes that determine the substrate specificity and are involved in cancer. Several recent studies shed light on the functions and mechanisms of HECTD3 E3 ubiquitin ligase. This review describes the progress in the recent studies of HECTD3 in cancer and other ...
Targeting ubiquitin E3 ligases may provide a novel strategyfor the prevention of the progression of atherosclerosis.doi:10.2174/0929867327666200306124418Zhou, Zhi-XiangRen, ZhongYan, Bin-JieQu, Shun-LinTang, Zhi-HanWei, Dang-HengLiu, Lu-Shan
Antigen-specific immunotolerance limits the expansion of self-reactive T cells involved in autoimmune diseases. Here, we show that the E3 ubiquitin ligase Cbl-b is upregulated in T cells after tolerizing signals. Loss of Cbl-b in mice results in impaired induction of T cell tolerance both in...
Using mass spectrometry-based phosphoproteomics, we have identified the RING finger E3 ubiquitin ligase RNF157 as a target at the intersection of PI3K and MAPK signaling. We demonstrate that RNF157 phosphorylation downstream of the PI3K and MAPK pathways influences the ubiquitination and stability of ...
Here we show that expression of the E3 ubiquitin ligase Grail is upregulated in CD8 T cells that have infiltrated into transplanted lymphoma tumours, and Grail deficiency confers long-term tumour control. Importantly, therapeutic transfer of......
The Role of E3 Ubiquitin Ligase Cbl Proteins in β-Elemene Reversing Multi-Drug Resistance of Human Gastric Adenocarcinoma Cells Ye Zhang,Xiao-Dong Mu,En-zhe LI,et al.The role of E3 ubiquitin ligase Cbl proteins in β-elemene reversing multi-drug resistance of human gastric ... Y Zhang,XD...
The ubiquitination of proteins in the cells of the testis occurs in many of the processes required for the progression of mature spermatozoa. Since it is the E3 ubiquitin ligase that recognizes the target protein and provides the specificity and selectivity for ubiquitination, this review highlights ...
Callaway K, Velasquez M, Brecht E, Nguyen L, Shaler T, Walker D, Yang Y, Regnstrom K, Diep L, Zhang Z, Chiou S, Bova M, Artis DR, Yao N, Baker J, Yednock T, Johnston JA (2013) Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases. Na...
We found that the HECT-type E3 ubiquitin ligase WWP2, a major NEDD4 family member, but not WWP1, another member of the NEDD4 family, was involved in endothelial injury and vascular remodeling after endothelial injury as a novel regulatory factor. Endothelial/myeloid-specific WWP2 knockout in ...