L1 and promotes the degradation of PD-L1 [47,48]. In addition, cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and its ligand (B7) are also regulated by E3 ligase, implying that E3 ligases have an effect on tumor immunosuppression in the CTLA4/B7 axis [49–55]. Inhibitin...
RNF8泛素连接酶环域对TPP1的稳定性和在端粒上的保留至关重要。RNF8与TPP1发生物理相互作用，产生Ubc13...
E3泛素连接酶MUL1抗体应用:可以用于做石蜡切片免疫组化,冰冻切片免疫组化,Elisa,WB,免疫荧光等实验。 英文名称Anti-MUL1/RNF218 中文名称E3泛素连接酶MUL1抗体 别名E3 ubiquitin-protein ligase MUL1; C1orf166; E3 ubiquitin ligase; E3 ubiquitin protein ligase MUL1; GIDE; Growth inhibition and death E3 ...
Key words: plant pathology; RING; E3 ubiquitin ligase; stress resistance; disease resistance 0 引言泛素是一个由 76 个氨基酸残基组成的高度保守的多肽,广泛分布于各类细胞,被泛素标记的蛋白质将被特异性识别,其中多聚泛素化的蛋白将被特异性降解从而调控细胞周期,信号传导,DNA 修复,细胞凋亡等过程。而单泛素...
E3 ubiquitin ligasetargeted protein degradationbinding ligandsmolecular gluesBifunctional degrader molecules, also called proteolysis-targeting chimeras(PROTACs),area new modality of chemical tools and potential therapeuticsto understand and treat human disease.Arequired PROTACcomponent isaligand binding to an ...
产品名称: 泛素蛋白连接酶 E3 成分 N- 识别蛋白 4(UBR4) 重组蛋白 英文名称:Recombinant Ubiquitin Protein Ligase E3 Component N-Recognin 4 (UBR4) 别名:RBAF600; p600; ZUBR1; Zinc Finger,UBR1 Type 1; N-reco
产品名称：E3 ligase Ligand 21 英文名称：E3 ligase Ligand 21 状态：固体/粉末/溶液 产品规格：mg 保存：冷藏 储藏条件：-20℃ 储存时间：1年 用途：科研 温馨提醒：仅供科研，不能用于人体实验 产品名称：F-PEG2-SO-COOH 英文名称：F-PEG2-SO-COOH 状态：固体/粉末/溶液 产品规格：mg 保存：冷藏 储藏...
PROTAC的迷人之处即在于,不同于常规小分子药物抑制一个靶点,他的目标是整个毁掉靶点:在POI ligand端连上目标靶点后,另一头的E3 ligase ligand端即将E3 ligase引来;随E3 ligase接踵而至的泛素(ubiquitin)如一张张罚单贴上靶点,等到罚单累积到一定水平,整个靶点随之被降解。众所周知,蛋白质是人体内最主要的功能高分...
Guided by an unbiased screening, we discovered that E3 ubiquitin ligase Ligand of Numb proteins X1/2 (LNX1/2) modulate the ubiquitination status of GlyT2. The N-terminal RING-finger domain of LNX1/2 ubiquitinates a cytoplasmic C-terminal lysine cluster in GlyT2 (K751, K773, K787 and ...
E3 ligase Ligand 10,CAS:1073560-68-5,E3 ligase Ligand 10 是一种 E3 泛素连接酶配体。E3 ligase Ligand 10 可以通过 linker 与靶蛋白配体连接,形成 PROTAC 或 SNIPER。PROTAC 可诱导促癌蛋白发生泛素化降解。