2022年6月29日,来自哈佛大学的Tom A. Rapoport和Peiqiang Feng共同通讯,在Nature在线发表了题为A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel的科研论文,文章中作者发现E3连接酶复合物中央存在孔道结构,Pex5经由该孔道由过...
MacquarieHoganMacquarieAlisonMacquarieL.MacquarieThe international journal of biochemistry and cell biologyGalper J, Rayner SL, Hogan AL, Fifita JA, Lee A, Chung RS, Blair IP and Yang S: Cyclin F: A component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer. Int J...
2022年2月3日,加州大学伯克利分校的Michael Rapé研究小组在MolecularCell杂志上发表题为Co-adaptor driven assembly of a CUL3 E3 ligase complex的研究论文,在这篇研究论文中,作者证明了单个CRL复合物的形成是一个严格调控的过程。以CUL3KLHL12为例,它的共衔接蛋白PEF1-ALG2在单泛素化底物修饰之前,通过内质网的组...
VHL基因所产生的蛋白为pVHL,在细胞中具有多种作用,且在细胞核和胞质之间移动。该蛋白最广为人知的功能也就是与Von Hippel-Lindau(VHL)综合征紧密相关的情况,具体涉及和其他蛋白形成复合体而生成泛素连接酶复合体(ubiquitin ligase complex)。...
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2–E3 enzyme cascade. Science 286, 1321–1326 (1999). Article CAS PubMed Google Scholar Verdecia, M.A. et al. Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Mol. ...
Targeted protein degradation is a powerful tool in determining the function of specific proteins or protein complexes. We fused nanobodies to SPOP, an adaptor protein of the Cullin-RING E3 ubiquitin ligase complex, resulting in rapid ubiquitination and s
한글명:Ubiquitin E3 Ligase Complex Antibody Sampler Kit카스 번호상품명:Ubiquitin E3 Ligase Complex Antibody Sampler KitCBNumberCB15703460포뮬러 무게0MOL 파일Mol fileUbiquitin E3 Ligase Complex Antibody Sampler Kit 공급 업체 ...
Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex Mutations of von Hippel-Lindau disease (VHL) tumor-suppressor gene product (pVHL) are found in patients with dominant inherited VHL syndrome and in the vas... K Iwai,K Yamanaka,T...
泛素连接酶ELISA试剂盒价格:￥1510/盒产品详情:试剂盒性能:产品名称:泛素连接酶ELISA试剂盒英文名称:Ubiquitin Protein Ligase检测范围:0.25ng/mL~8ng/mL。灵敏度:0.1。特... 纯度:详见说明书% 包装规格:48T/96T 用途:仅用于科研 货号:EY2494 品牌:莼试 ...
TheAPCE3ubiquitin ligaseconsists of at least 12 proteins. TheRING finger protein, APC11, and the Cul1-relatedscaffold protein, APC2, form the catalytic core of the complex, but the functions of many of the other subunits have not been fully delineated (Fig. 1). APCsubstrate specificityis co...