2022年6月29日,来自哈佛大学的Tom A. Rapoport和Peiqiang Feng共同通讯,在Nature在线发表了题为A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel的科研论文,文章中作者发现E3连接酶复合物中央存在孔道结构,Pex5经由该孔道由过...
E3 ubiquitin ligase complex: E3 ubiquitin ligases are responsible for the final step of ubiquitination, the covalent attachment of ubiquitin to a target protein. They are composed of multiple subunits, including: RING finger domain-containing proteins: These proteins contain a RING finger domain, whic...
复旦大学生命科学学院王陈继副研究员和医学院病理系章平肇副研究员、哥伦比亚大学顾伟教授、上海市第一妇婴保健院高昆研究员合作,在2021年11月7日Cell Death & Differentiation杂志在线发表了题为“CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARFdegradation”的最新研究成果。 铁...
复旦大学生命科学学院王陈继副研究员和医学院病理系章平肇副研究员、哥伦比亚大学顾伟教授、上海市第一妇婴保健院高昆研究员合作,在2021年11月7日Cell Death & Differentiation杂志在线发表了题为“CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation”的最新研究成果。 C...
[4] RapidProgressin the Use of Immunomodulatory Drugs and Cereblon E3 Ligase Modulators in the Treatment of Multiple Myeloma. Cancers 2021, 13, 4666. [5] CRL4 E3 Ligase Complex as a Therapeutic Target in Multiple Myeloma.[J] .Cancers (Basel), 2022, 14: undefined. ...
Over the past two decades, important strides have been made in developing small molecule-based protein degraders1,4,5. Typically, these involve heterobifunctional molecules such as PROTACs1and molecular glues6that form a ternary complex with an E3 ubiquitin ligase and a target of interest, resultin...
Both PROTACs and molecular glues induce proximity between a protein of interest (POI) and an E3 ubiquitin ligase complex, leading to formation of a ternary complex and transfer of ubiquitin molecules. The poly-ubiquitinated POI is recruited to the proteasome and subsequently degraded. Molecular glues...
复旦大学生命科学学院王陈继副研究员和医学院病理系章平肇副研究员、哥伦比亚大学顾伟教授、上海市第一妇婴保健院高昆研究员合作,在2021年11月7日Cell Death & Differentiation杂志在线发表了题为“CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARFdegradation”的最新研究成果。
E3 ubiquitin ligases, especially the SCF (Skp1-Cul1-F-box protein) and APC (Anaphase-promoting complex, also known as APC/C), have been extensively studied in the past decades. These two ubiquitin E3 ligases primarily function in the regulation of cell cycle progression through timely and ...
2022年2月3日,加州大学伯克利分校的Michael Rapé研究小组在MolecularCell杂志上发表题为Co-adaptor driven assembly of a CUL3 E3 ligase complex的研究论文,在这篇研究论文中,作者证明了单个CRL复合物的形成是一个严格调控的过程。以CUL3KLHL12为例,它的共衔接蛋白PEF1-ALG2在单泛素化底物修饰之前,通过内质网的组...