2.1.1The E3 ubiquitin ligase MIB1 The E3 ubiquitin-proteinligaseMindbomb 1 (MIB1) was first identified for its function in Notch-Delta signaling in human cells, where it promotesubiquitinationandinternalizationof Delta[29]. Upon further analysis, the survivalmotor neuron(SMN) protein was ...
smurf1是一个E3ubiquitin ligase,指定目标proteasomal ubiquitination和退化。 以学习的是否具有约束力的smurf导致退化的1次,2013-05-23 12:23:18 回答:匿名 Smurf1是为ubiquitination和proteasomal退化指定目标的E3 ubiquitin连接酶。 学会Smurf1捆绑是否导致TH的退化, 2013-05-23 12:24:58 回答:匿名Smurf1 是 E3 ...
An E3 ubiquitin ligase from Brassica napus induces a typical heat-shock response in its own way in Escherichia coil 泛素连接酶甘蓝型油菜大肠杆菌热激反应热休克反应HSP70热休克蛋白热耐受性以前,我们识别了新奇 E3 ubiquitin ligase, BNTR1,哪个戏在在 Brassica 马来麝的发情压力反应的一个关键角色.在这研究...
smurf1是一个E3ubiquitin ligase,指定目标和proteasomal ubiquitination 匿名 2013-05-23 12:24:58 Smurf1是为ubiquitination指定目标和proteasomal的E3 ubiquitin连接酶 匿名 2013-05-23 12:26:38 Smurf1 是 E3 泛素连接酶,它指定泛和大鼠的目标 匿名 2013-05-23 12:28:18 Smurf1 是 E3 泛素连接酶,...
MYCBP2 contains two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates. Crystallographic characterization of this class of E3 ligase, which we designate RING-Cys-relay (RCR), provides insights into its mechanism and threonine selectivity. These findings...
CUL3 is a tumor suppressor gene encoding a core scaffolding protein in an E3 ubiquitin ligase complex that includes KEAP1 and RBX1, which plays a role in the oxidative stress response pathway. From: Encyclopedia of Cancer (Third Edition), 2019 ...
We also noticed that MCL-1 is reported to act as a suppressor of AMBRA1 to suppress mitophagy, under the conditions of FCCP or CCCP treatment38. It is reported that AMBRA1-mediated mitophagy is regulated by HUWE1, an E3 ubiquitin ligase, which could control mitochondrial protein ubiquitylation...
Functional dissection of an HECT ubiquitin E3 ligase 来自 Semantic Scholar 喜欢 0 阅读量: 62 作者: JY Lu,YY Lin,J Qian,SC Tao,J Zhu,C Pickart,H Zhu 展开 摘要: Ubiquitination is one of the most prevalent protein posttranslational modifications in eukaryotes, and its malfunction is ...
Mandel SA, Fishman-Jacob T, Youdim MB. Targeting Skp1, an ubiquitin E3 ligase component found decreased in sporadic Parkinson's disease. Neurodegener Dis. 2011; 10 :220–223.Mandel SA, Fishman-Jacob T, Youdim MBH. Targeting Skp1, an Ubiquitin E3 Ligase Component Found Decreased in ...
This shows that BOP proteins act as substrate adaptors in a CUL3BOP1/BOP2E3 ubiquitin ligase complex, targeting PIF4 proteins for ubiquitination and subsequent degradation. 展开 关键词: A. thaliana DOI: 10.7554/elife.26759 被引量: 9