其他别名:Paratyphoid B Fever Paratyphoid C Fever Paratyphoid Fever a Paratyphoid Fever B Paratyphoid Fever C 疾病简介:副伤寒,又称为副伤寒b,与沙门氏菌病和伤寒有关,症状包括便秘、发热和腹痛。与副伤寒相关的基因是PRKN(Parkin RBR E3 Ubiquitin Protein Ligase),其相关通路/超级通路包括先天免疫系统和MIF介...
Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson’s disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superfluous...
Mutations in the E3 ubiquitin ligase parkin (PARK2, also known as PRKN) and the protein kinase PINK1 (also known as PARK6) are linked to autosomal-recessive juvenile parkinsonism (AR-JP)1,2; at the cellular level, these mutations cause defects in mitopha
作用机制 PRKN激活剂(parkin RBR E3 ubiquitin protein ligase activators) 治疗领域 神经系统疾病内分泌与代谢疾病 在研适应症 帕金森病 非在研适应症- 原研机构 Nine Square Therapeutics, Inc.初创企业 在研机构 Nine Square Therapeutics, Inc.初创企业 非在研机构- 最高研发阶段临床前 首次获批日期- 最高研发阶...
PARK2 (also known as Parkin RBR E3 ubiquitin protein ligase) is one of the largest genes in our genome. It undergoes an extensive alternative splicing both at transcript and protein level, producing multiple transcript variants and disti... VL Cognata,S Cavallaro - 《Atlas of Genetics & Cyto...
On the other hand, changes in parkin (parkin RBR E3 ubiquitin protein ligase) expression patterns have been described in several diseases, including breast cancer. Nevertheless, the association of these changes with cancer prognostic and predictive factors remains unclear. Also, parkin regulates APEX1...
the ubiquitin ligases responsible for catalysing ubiquitin chains that surround intracellular bacteria are poorly understood. The parkin protein is a ubiquitin ligase with a well-established role in mitophagy, and mutations in the parkin gene (PARK2) lead to increased susceptibility to Parkinson’s dise...
parkin RBR E3 ubiquitin protein ligase , AR-JP , LPRS2 , PARK2 , PDJ 细胞定位 Cytoplasm, cytosol,Nucleus,Endoplasmic reticulum,Mitochondrion 功能与背景 The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex ...
基因名全称parkin RBR E3 ubiquitin protein ligase 蛋白名全称E3 ubiquitin-protein ligase parkin 推荐稀释比 Western blot(WB) 1:500~2000 Immunohistochemistry in paraffin section (IHC) 1:50~400 Immunocytochemistry 1:50~400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA re...
蛋白别名: E3 ubiquitin-protein ligase parkin; OTTHUMP00000017562; OTTHUMP00000017563; OTTHUMP00000017564; parkin 2; Parkin isoform 1; Parkin RBR E3 ubiquitin-protein ligase; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson protein 2, E3 ubiquitin protein...