It isgenerallybelievedthatthelossoftheE3ligaseactivityofparkinimpairsdegradation of altered, unwanted protein species by the proteasomesystem [7]. It is conceivable that parkin, in addition to proteasomaldegradation, modulates, directly or by ubiquitination, factors thatcontrol the expression of different ...
PRKN/PARK2: parkin RBR E3 ubiquitin protein ligase; ROS: reactive oxygen species; TM: transmembrane; Ub: ubiquitin; UBA1: ubiquitin like modifier activati... K Niu,H Fang,Z Chen,... - 《Autophagy》 被引量: 0发表: 2020年 PRKN (arkin RBR E3 ubiquitin protein ligase ) PARK2 (also know...
novel probes for rbr e3 ubiquitin ligase parkin 来自 钛学术 喜欢 0 阅读量: 25 作者: park, sungjin , foote, peter k , krist, david t , rice, sarah e , statsyuk, alexander v 摘要: ring-between-ring (rbr) e3 ligases have been implicated in autoimmune disorders and neurodegenerative ...
genefusion,suggestedthatRBRproteinsmaybeoftenpartofcullin-containing ubiquitinligasecomplexes.RecentdataonParkinproteinagreeswiththathypoth- esis.WediscusstheinvolvementofRBRproteinsinseveralneurodegenerative diseasesandcancer. Parkinsondisease;proteinqualitycontrol;transcriptionalregulation ...
The human RBR E3 ligase Parkin is captured in complex with phosphoubiquitin, revealing a cryptic ubiquitin-binding site and indicating a mechanism of cooperation between RBR modules for activation. RING-between-RING (RBR) E3 ligases are a class of ubiqui
UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN Author links open overlay panelSungjin Park ‡ 1, Peter K. Foote §, David T. Krist § 2, Sarah E. Rice ‡ 1, Alexander V. Statsyuk § ¶ 1Show more Add to Mendeley Share Cite...
PARKIN is a RING-Between-RING (RBR) E3 ligase, which ubiquitinates mitochondrial proteins in response to mitochondrial damage. Ser65 of PARKIN is phosphorylated by kinase PINK1 (pPARKIN), which causes partial PARKIN activation. PINK1 also phosphorylates Ser65 of ubiquitin (pUb), which further...
Parkin encodes a ubiquitin-protein ligase characterized by having the RBR domain, composed of two RING fingers plus an IBR/DRIL domain. The RBR family is defined as the group of genes whose products contain an RBR domain. RBR family members exist in all eukaryotic species for which significant...
UbMES and UbFluor: Novel Probes For RBR E3 Ubiquitin Ligase PARKIN Ring-Between-Ring (RBR) E3 ligases have been implicated in autoimmune disorders and neurodegenerative diseases. The functions of many RBR E3s are poorly defined and their regulation is complex, involving posttranslational modifications...