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Parp9 undergoes heterodimerization with Dtx3L, a histone E3 ligase involved in DNA damage repair. We show that the Dtx3L/Parp9 heterodimer mediates NAD+-dependent mono-ADP-ribosylation of ubiquitin, exclusively in the context of ubiquitin processing by E1 and E2 enzymes. Dtx3L/Parp9 ADP-ribosyl...
产品别名: Smad ubiquitination regulatory factor 1; Smad ubiquitination regulatory factor 1; Smad specific E3 ubiquitin ligase 1; E3 ubiquitin-protein ligase SMURF1; hSMURF1; Smad specific E3 ubiquitin ligase 1; SMAD specific E3 ubiquitin protein ligase 1; Smad ubiquitination regulatory factor 1; SMA...
endruleubiquitinligaseUBR2anddetectitsexpressionefficiencyinHepG2cells.MethodTotalRNAwasextractedfromHepG2cells,andthenUBR2genewasamplifiedbyRT-PCRandinsertedintotheeukaryoticexpressionvectorpEGFP-N2.TherecombinantplasmidpEGFP-N2-UBR2wastransfectedintoHepG2cells.TheexpressionofUBR2wasobservedbyfluorescentmicroscopy...
amplified HTT, depending on its ubiquitination activity. SilentUBR5results in mHTT aggregates in HD iPSCs. Other E3s highly expressed in iPSCs have not been reported to exert such a role, such as UBR7, ubiquitin protein ligase E3A (UBE3A), and RNF181. They deserve attention and study [...
Therefore, there may be vital members of the SCF E3 ubiquitin ligase family, which could drive pro-tumorigenesis. Being the largest family of E3 ubiquitin ligases, the SCF is composed of four components: SKP1, a cullin, an F-box protein, and RBX1 or RBX2. This multimeric complex is ...