Nedd4l (neural precursor cell-expressed developmentally down-regulated 4-like, also known as Nedd4-2) is a HECT E3 ubiquitin ligase of the Nedd4 family. Nedd4l regulates a number of membrane proteins, such as the epithelial and voltage-gated sodium channels19. In TGF-β signaling, Nedd4l...
别名AIP 5; AIP5; Atropin-1-interacting protein 5; hSDRP1; nedd4 like; NEDD4-like E3 ubiquitin-protein ligase WWP1; Tiul1; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1; WWP 1; WWP1_HUMAN.
Therefore, there may be vital members of the SCF E3 ubiquitin ligase family, which could drive pro-tumorigenesis. Being the largest family of E3 ubiquitin ligases, the SCF is composed of four components: SKP1, a cullin, an F-box protein, and RBX1 or RBX2. This multimeric complex is ...