R., Liu, Y. Y., Zhang, Y. J., Zhang, X. Z., et al. (2015). The E3 ubiquitin ligase seven in absentia homolog 1 may be a potential new therapeutic target for Parkinson's disease. Neural Regen. Res. 10, 1286-1291. doi: 10.4103/1673-5374.162763...
2022年8月3日,中科院植物所林荣呈研究组以“The RNA helicase UAP56 and the E3 ubiquitin ligase COP1 coordinately regulate alternative splicing to repress photomorphogenesis in Arabidopsis”为题的研究论文在期刊“The Plant Cell”上在线发表,该研究阐明了UAP56与COP1共同通过调节下游基因可变剪接来调控光形态建成...
Wnt-induced degradation of CK1α requires CRBN, the substrate receptor of the CRL4CRBNE3 ubiquitin ligase complex We noted that a pan-inhibitor of the RING-finger family of E3 ubiquitin ligases, MLN4924, attenuated Wnt3a-induced CK1α degradation (Supplementary Fig.2a). We, therefore, evaluated ...
impairs antiviral immune responses and rescues autoimmune lethality caused by TREX1 deficiency. A recent study has shown that the E3 ubiquitin ligase TRIM38 targets cGAS for SUMOylation, which suppresses the K48-linked polyubiquitination of cGAS in a manner of physical hindrance and stabilizes cGAS ...
Kny, X. Zhu et al., "The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy," Critical Care, vol. 18, no. 5, 2014.Schmidt, F. et al. The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy. Critical care 18, 545 (2014)....
GC B cellsitchplasma cellsDeficiency of Itch, an E3 ubiquitin ligase, usually induced severe systemic and progressive autoimmune disease. The Itch function is well studied in T cells but not in B cells. We hypothesize that B-cell-specific Itch deficiency promoted antigen-induced B-cell activation...
Collectively, we find that selective regulation of AR transcriptional activity by the ubiquitin ligase Siah2 is important for CRPC development. Highlights ► A subset of chromatin-bound AR is regulated by Siah2, in concert with NCOR1 ► Siah2 regulates select AR target genes implicated in ...
The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I Author links open overlay panelChunyuan Zhao 1 5, Mutian Jia 2 3 5, Hui Song 2 3, Zhongxia Yu 2 3, Wenwen Wang 2 3, Qi Li 2 3, Lining Zhang 2, Wei Zhao 2 3, Xuetao Cao 1 4 6...
PatiñoGarcía, AnaLecanda, FernandoFromigué, OliviaMarie, Pierre JSevere N, Dieudonne F-X, Marty C, et al. Targeting the E3 ubiquitin ligase c-Cbl decreases osteosarcoma cell growth and survival and reduces tumorigenesis. J Bone Miner Res 2012 ; 27 : 2108-17....
a泛素连接酶(E3)是真核生物体内蛋白质选择性降解系统(UPS)的关键因子,调节着真核细胞内的多种生理生化反应。 Exudes element ligase (E3) is in the really nuclear organism the protein selectivity degeneration system (UPS) essential factor, is adjusting in the really nuclear cell many kinds of physiologi...