E3-ubiquitin ligaseprotein degradationrubylationSCF complexubiquitylationSCF-type E3-ubiquitin ligases control numerous cellular processes through the ubiquitin-proteasome pathway. However, the regulation of SCF function remains largely uncharacterized. Here, we report a novel SCF complex-interacting protein, ...
The abundance of the cyclin-dependent kinase (CDK) inhibitor p57Kip2, an important regulator of cell cycle progression, is thought to be controlled by the ubiquitin-proteasome pathway. The Skp1/Cul1/F-box (SCF)-type E3 ubiquitin ligase complex SCFSkp2 has now been shown to be responsible fo...
HES1 is a target for the E3 ubiquitin ligase SCFFBXL14 complex resulting in HES1 proteolysis, which further enhances neuronal differentiation [158]. Similarly to Notch receptors, the Notch ligands also have EGF-repeats in their ECD, which can be modified by glycosylation, but the functional ...
The F-box protein S-phase kinase-associated protein 2 (Skp2) is an essential subunit of the Skp1-Cullin-1-F-box (SCF) ubiquitin E3 ligase complex. Skp2 harbors the E3 ligase activity, which is required for substrate recognition of the SCF complex [7]. Previous studies have shown that ...
The process of covalently attaching ubiquitin to another protein. Ubiquitylation is accomplished via an enzymatic cascade of an E1 ubiquitin activating enzyme, an E2 ubiquitin conjugating enzyme, and an E3 ubiquitin ligase. Proteasome A large protein complex that catalyses the proteolytic destruction of...
英文名称:Recombinant Talaromyces stipitatus E3 ubiquitin ligase complex SCF subunit sconC sconCRecombinant Talaromyces stipitatus E3 ubiquitin ligase complex SCF subunit sconC sconC is available 2 ,中文名称:重组Stiptatus Talaromyces E3泛素连
Centromere pairing is crucial for synapsis in meiosis. This study delves into the Skp1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex, specifically focusing on F-box protein 47 (FBXO47), in mouse meiosis. Here, we revealed that FBXO47 is localiz
Here we report that ZNRF3 is accumulated in the presence of proteasome inhibitor treatment independent of its E3-ubiquitin ligase activity. Furthermore, the Cullin 1-specific SCF complex containing β-TRCP has been identified to directly interact with and ubiquitinate ZNRF3 thereby regulating its ...
The F-box protein is the substrate recognition subunit of SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase complex, a multicomponent RING-type E3 ligase involved in the regulation of numerous cellular processes by targeting critical regulatory proteins for ubiquitination. However, whether and how F-box ...
The invention provides ubiquitin variants that specifically bind to SCF E3 ligases, and use of these variants to modulate the activity of SCF E3 ligases.